3SP7

Crystal Structure of Bcl-xL bound to BM903

Summary for 3SP7

• Entry DOI: 10.2210/pdb3sp7/pdb
• Related: 3SPF
• Descriptor: Bcl-2-like protein 1, 5-(4-chlorophenyl)-4-{3-[4-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]amino}phenyl)piperazin-1-yl]phenyl}-1,2-dimethyl-1H-pyrrole-3-carboxylic acid, ZINC ION, ... (5 entities in total)
• Functional Keywords: bcl-2-like protein, apoptosis regulator-inhibitor complex, apoptosis regulator/inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817
• Total number of polymer chains: 1
• Total formula weight: 21023.88

Authors

Meagher, J.L.,Stuckey, J.A. (deposition date: 2011-07-01, release date: 2012-07-04, Last modification date: 2024-02-28)

• Primary citation: Zhou, H.,Chen, J.,Meagher, J.L.,Aguilar, A.,Bai, L.,Liu, L.,Yang, C.Y.,Xin, C.,Stuckey, J.A.,Wang, S.; Structure-based design of a new class of potent Bcl-2/Bcl-xL inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (1.4 Å)