5KNL
 
 | | Crystal structure of S. pombe ubiquitin E1 (Uba1) in complex with Ubc15 and ubiquitin | | Descriptor: | SULFATE ION, Ubiquitin, Ubiquitin-activating enzyme E1 1, ... | | Authors: | Olsen, S.K, Lv, Z, Yuan, L, Williams, K. | | Deposit date: | 2016-06-28 | | Release date: | 2017-02-15 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
Mol. Cell, 65, 2017
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4WHV
 | | E3 ubiquitin-protein ligase RNF8 in complex with Ubiquitin-conjugating enzyme E2 N and Polyubiquitin-B | | Descriptor: | E3 ubiquitin-protein ligase RNF8, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 N, ... | | Authors: | Hodge, C.D, Edwards, R.A, Glover, J.N.M. | | Deposit date: | 2014-09-23 | | Release date: | 2015-09-30 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (8.3 Å) | | Cite: | RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.
J.Biol.Chem., 291, 2016
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4WZ3
 | | Crystal structure of the complex between LubX/LegU2/Lpp2887 U-box 1 and Homo sapiens UBE2D2 | | Descriptor: | E3 ubiquitin-protein ligase LubX, Ubiquitin-conjugating enzyme E2 D2 | | Authors: | Stogios, P.J, Quaile, A.T, Skarina, T, Nocek, B, Di Leo, R, Yim, V, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2014-11-18 | | Release date: | 2015-01-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila.
Structure, 23, 2015
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5L9U
 | | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination | | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | | Authors: | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | | Deposit date: | 2016-06-11 | | Release date: | 2016-09-14 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (6.4 Å) | | Cite: | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
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5L9T
 | | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density | | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | | Authors: | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | | Deposit date: | 2016-06-11 | | Release date: | 2016-10-26 | | Last modified: | 2016-11-02 | | Method: | ELECTRON MICROSCOPY (6.4 Å) | | Cite: | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
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4X57
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5MNJ
 | | Structure of MDM2-MDMX-UbcH5B-ubiquitin complex | | Descriptor: | E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, Protein Mdm4, ... | | Authors: | Klejnot, M, Huang, D.T. | | Deposit date: | 2016-12-13 | | Release date: | 2017-05-31 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.
Nat. Struct. Mol. Biol., 24, 2017
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4Y1L
 | | Ubc9 Homodimer The Missing Link in Poly-SUMO Chain Formation | | Descriptor: | RWD domain-containing protein 3, SUMO-conjugating enzyme UBC9 | | Authors: | Aileen, Y.A, Ambaye, N.D, Li, Y.J, Vega, R, Bzymek, K, Williams, J.C, Hu, W, Chen, Y. | | Deposit date: | 2015-02-08 | | Release date: | 2015-05-06 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | RWD Domain as an E2 (Ubc9)-Interaction Module.
J.Biol.Chem., 290, 2015
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4YII
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3E46
 | | Crystal structure of ubiquitin-conjugating enzyme E2-25kDa (Huntington interacting protein 2) M172A mutant | | Descriptor: | CALCIUM ION, Ubiquitin-conjugating enzyme E2-25 kDa | | Authors: | Hughes, R.C, Wilson, R.C, Flatt, J.W, Meehan, E.J, Ng, J.D, Twigg, P.D. | | Deposit date: | 2008-08-09 | | Release date: | 2008-08-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2).
Acta Crystallogr.,Sect.F, 65, 2009
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8ATX
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8AUW
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8ATU
 | | Cryo-EM structure of human BIRC6 | | Descriptor: | Baculoviral IAP repeat-containing protein 6, ZINC ION | | Authors: | Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. | | Deposit date: | 2022-08-24 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Science, 379, 2023
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8AUK
 | | Cryo-EM structure of human BIRC6 in complex with HTRA2. | | Descriptor: | Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial, ... | | Authors: | Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. | | Deposit date: | 2022-08-25 | | Release date: | 2023-02-15 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Science, 379, 2023
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8ATM
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8ATO
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8OIF
 | | Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6 | | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | | Authors: | Wallace, I, Kheewoong, B, Prabu, J.R, Vollrath, R, von Gronau, S, Schulman, B.A, Swatek, K.N. | | Deposit date: | 2023-03-22 | | Release date: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Insights into the ISG15 transfer cascade by the UBE1L activating enzyme.
Nat Commun, 14, 2023
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8JWJ
 | | PHD Finger Protein 7 (PHF7) in complex with UBE2D2 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, PHD finger protein 7, ... | | Authors: | Lee, H.S, Bang, I, Choi, H.-J. | | Deposit date: | 2023-06-29 | | Release date: | 2023-12-20 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.96 Å) | | Cite: | Molecular basis for PHF7-mediated ubiquitination of histone H3.
Genes Dev., 37, 2023
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8JWU
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3EB6
 | | Structure of the cIAP2 RING domain bound to UbcH5b | | Descriptor: | Baculoviral IAP repeat-containing protein 3, Ubiquitin-conjugating enzyme E2 D2, ZINC ION | | Authors: | Mace, P.D, Linke, K, Schumacher, F.-R, Smith, C.A, Day, C.L. | | Deposit date: | 2008-08-27 | | Release date: | 2008-09-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment.
J.Biol.Chem., 283, 2008
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6IF1
 | | Crystal structure of Ube2K and K48-linked di-ubiquitin complex | | Descriptor: | Ubiquitin, Ubiquitin-conjugating enzyme E2 K | | Authors: | Lee, J.-G, Youn, H.-S, Lee, Y, An, J.Y, Park, K.R, Kang, J.Y, Lim, J.J, Eom, S.H. | | Deposit date: | 2018-09-18 | | Release date: | 2018-11-21 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.466 Å) | | Cite: | Crystal structure of the Ube2K/E2-25K and K48-linked di-ubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis.
Biochem. Biophys. Res. Commun., 506, 2018
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6KG6
 | | Crystal structure of MavC/UBE2N-Ub complex | | Descriptor: | MavC, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 N | | Authors: | Wang, Y, Huang, Y, Chang, M, Feng, Y. | | Deposit date: | 2019-07-10 | | Release date: | 2020-04-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.
Nat Commun, 11, 2020
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8B3I
 | | CRL4CSA-E2-Ub (state 2) | | Descriptor: | Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ... | | Authors: | Kokic, G, Cramer, P. | | Deposit date: | 2022-09-16 | | Release date: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | C(N)RL4CSA-E2-Ub (state 2)
To Be Published
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3FN1
 | | E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. | | Descriptor: | NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F | | Authors: | Huang, D.T, Ayrault, O, Hunt, H.W, Taherbhoy, A.M, Duda, D.M, Scott, D.C, Borg, L.A, Neale, G, Murray, P.J, Roussel, M.F, Schulman, B.A. | | Deposit date: | 2008-12-22 | | Release date: | 2009-03-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Mol.Cell, 33, 2009
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3RCZ
 | | Rad60 SLD2 Ubc9 Complex | | Descriptor: | DNA repair protein rad60, SUMO-conjugating enzyme ubc9 | | Authors: | Perry, J.J.P, Arvai, A.S, Tainer, J.A. | | Deposit date: | 2011-03-31 | | Release date: | 2011-04-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.
Mol.Cell.Biol., 31, 2011
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