E3 ubiquitin-protein ligase RNF8 in complex with Ubiquitin-conjugating enzyme E2 N and Polyubiquitin-B

Summary for 4WHV

DescriptorUbiquitin-conjugating enzyme E2 N, E3 ubiquitin-protein ligase RNF8, Polyubiquitin-B, ... (4 entities in total)
Functional Keywordse3 ligase, e2 conjugating enzyme, ubiquitination, coiled coil, ligase-protein binding complex, ligase/protein binding
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  P61088 O76064
Ubiquitin: Cytoplasm  P0CG47
Total number of polymer chains12
Total molecular weight180150.1
Hodge, C.D.,Edwards, R.A.,Glover, J.N.M. (deposition date: 2014-09-23, release date: 2015-09-30, Last modification date: 2017-11-22)
Primary citation
Hodge, C.D.,Ismail, I.H.,Edwards, R.A.,Hura, G.L.,Xiao, A.T.,Tainer, J.A.,Hendzel, M.J.,Glover, J.N.
RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.
J.Biol.Chem., 291:9396-9410, 2016
PubMed: 26903517 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M116.715698
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.34171.1%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report