8ATO

Structure of the giant inhibitor of apoptosis, BIRC6 bound to the regulator SMAC

This is a non-PDB format compatible entry.

Summary for 8ATO

• Entry DOI: 10.2210/pdb8ato/pdb
• Related: 8ATM
• EMDB information: 15654
• Descriptor: Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein (2 entities in total)
• Functional Keywords: e2/e3 ubiquitin ligase, apoptosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 1103528.20

Authors

Dietz, L.,Elliott, P.R. (deposition date: 2022-08-23, release date: 2023-03-08, Last modification date: 2023-03-29)

• Primary citation: Dietz, L.,Ellison, C.J.,Riechmann, C.,Cassidy, C.K.,Felfoldi, F.D.,Pinto-Fernandez, A.,Kessler, B.M.,Elliott, P.R.; Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6.; Science, 379:1112-1117, 2023; PubMed: 36758106; DOI: 10.1126/science.ade8840

Experimental method

ELECTRON MICROSCOPY (3 Å)