5MNJ

Structure of MDM2-MDMX-UbcH5B-ubiquitin complex

Summary for 5MNJ

• Entry DOI: 10.2210/pdb5mnj/pdb
• Descriptor: Ubiquitin-conjugating enzyme E2 D2, Polyubiquitin-B, E3 ubiquitin-protein ligase Mdm2, ... (7 entities in total)
• Functional Keywords: ubiquitin ligase, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 86014.67

Authors

Klejnot, M.,Huang, D.T. (deposition date: 2016-12-13, release date: 2017-05-31, Last modification date: 2024-01-17)

• Primary citation: Nomura, K.,Klejnot, M.,Kowalczyk, D.,Hock, A.K.,Sibbet, G.J.,Vousden, K.H.,Huang, D.T.; Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.; Nat. Struct. Mol. Biol., 24:578-587, 2017; PubMed: 28553961; DOI: 10.1038/nsmb.3414

Experimental method

X-RAY DIFFRACTION (2.16 Å)