5MNJ

Structure of MDM2-MDMX-UbcH5B-ubiquitin complex

Summary for 5MNJ

DescriptorUbiquitin-conjugating enzyme E2 D2, Polyubiquitin-B, E3 ubiquitin-protein ligase Mdm2, ... (7 entities in total)
Functional Keywordsubiquitin ligase, ligase
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total molecular weight86014.67
Authors
Klejnot, M.,Huang, D.T. (deposition date: 2016-12-13, release date: 2017-05-31, Last modification date: 2019-05-08)
Primary citation
Nomura, K.,Klejnot, M.,Kowalczyk, D.,Hock, A.K.,Sibbet, G.J.,Vousden, K.H.,Huang, D.T.
Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.
Nat. Struct. Mol. Biol., 24:578-587, 2017
PubMed: 28553961 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.3414
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.16 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22880 2.1% 1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution