5MNJ

Structure of MDM2-MDMX-UbcH5B-ubiquitin complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0032991	cellular_component	protein-containing complex
A	0036211	biological_process	protein modification process
A	0051865	biological_process	protein autoubiquitination
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070062	cellular_component	extracellular exosome
A	0070936	biological_process	protein K48-linked ubiquitination
C	0042802	molecular_function	identical protein binding
C	0061630	molecular_function	ubiquitin protein ligase activity
D	0005634	cellular_component	nucleus
D	0043066	biological_process	negative regulation of apoptotic process
D	0051726	biological_process	regulation of cell cycle
E	0000166	molecular_function	nucleotide binding
E	0000209	biological_process	protein polyubiquitination
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005829	cellular_component	cytosol
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0016567	biological_process	protein ubiquitination
E	0016740	molecular_function	transferase activity
E	0032991	cellular_component	protein-containing complex
E	0036211	biological_process	protein modification process
E	0051865	biological_process	protein autoubiquitination
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0061631	molecular_function	ubiquitin conjugating enzyme activity
E	0070062	cellular_component	extracellular exosome
E	0070936	biological_process	protein K48-linked ubiquitination
G	0042802	molecular_function	identical protein binding
G	0061630	molecular_function	ubiquitin protein ligase activity
H	0005634	cellular_component	nucleus
H	0043066	biological_process	negative regulation of apoptotic process
H	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN C 501

Chain	Residue
C	CYS438
C	CYS441
C	CYS461
C	CYS464

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN C 502

Chain	Residue
C	HIS452
C	HIS457
C	CYS475
C	CYS478

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN D 501

Chain	Residue
D	CYS440
D	CYS460
D	CYS463
D	CYS437

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN D 502

Chain	Residue
D	HIS451
D	HIS456
D	CYS474
D	CYS477

---

site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 D 503

Chain	Residue
D	ALA472
D	SER473
D	LYS478
E	ARG139
H	ALA472
H	SER473
H	LYS478

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN G 501

Chain	Residue
G	CYS438
G	CYS441
G	CYS461
G	CYS464

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN G 502

Chain	Residue
G	HIS452
G	HIS457
G	CYS475
G	CYS478

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN H 501

Chain	Residue
H	HIS451
H	HIS456
H	CYS474
H	CYS477

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN H 502

Chain	Residue
H	CYS437
H	CYS440
H	CYS460
H	CYS463

---

site_id	AD1
Number of Residues	6
Details	binding site for residue SO4 H 503

Chain	Residue
D	LYS442
D	ARG443
D	ARG466
H	LYS442
H	ARG443
H	ARG466

---

site_id	AD2
Number of Residues	10
Details	binding site for Di-peptide GLY F 76 and LYS E 85

Chain	Residue
E	HIS75
E	ASN77
E	ILE78
E	ILE84
E	LEU86
E	ASP117
E	LEU119
E	VAL120
E	TYR134
F	GLY75

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	75
Details	Domain: {"description":"Ubiquitin-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	164
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Motif: {"description":"Nucleolar localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by ATM","evidences":[{"source":"PubMed","id":"19816404","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---