8GAE
 
 | | Hsp90 provides platform for CRaf dephosphorylation by PP5 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... | | 著者 | Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. | | 登録日 | 2023-02-22 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
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7SS7
 | | Crystal structure of Klebsiella LpxH in complex with JH-LPH-50 | | 分子名称: | 1,2-ETHANEDIOL, 6-{[(4-{4-[3-chloro-5-(trifluoromethyl)phenyl]piperazine-1-sulfonyl}phenyl)carbamoyl]amino}-N-hydroxyhexanamide, MANGANESE (II) ION, ... | | 著者 | Cho, J, Cochrane, C.S, Zhou, P. | | 登録日 | 2021-11-09 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH.
Chemmedchem, 18, 2023
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7SS6
 | | Structure of Klebsiella LpxH in complex with JH-LPH-45 | | 分子名称: | 1,2-ETHANEDIOL, 5-{4-[3-chloro-5-(trifluoromethyl)phenyl]piperazine-1-sulfonyl}-N-[5-(hydroxyamino)-5-oxopentyl]-2,3-dihydro-1H-indole-1-carboxamide, MANGANESE (II) ION, ... | | 著者 | Cho, J, Cochrane, C.S, Zhou, P. | | 登録日 | 2021-11-09 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH.
Chemmedchem, 18, 2023
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7YCX
 | | The structure of INTAC-PEC complex | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y. | | 登録日 | 2022-07-02 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | | 主引用文献 | Structural basis of INTAC-regulated transcription.
Protein Cell, 14, 2023
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8DWK
 | | Inhibitor-3:PP1 reconstituted complex | | 分子名称: | E3 ubiquitin-protein ligase PPP1R11, MANGANESE (II) ION, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | | 著者 | Choy, M.S, Srivastava, G, Page, R, Peti, W. | | 登録日 | 2022-08-01 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction.
Nat Commun, 14, 2023
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8DWL
 | | Inhibitor-3:PP1 coexpressed complex | | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase PPP1R11, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, ... | | 著者 | Choy, M.S, Srivastava, G, Page, R, Peti, W. | | 登録日 | 2022-08-01 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction.
Nat Commun, 14, 2023
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7QWJ
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7ZR1
 | | Chaetomium thermophilum Mre11-Rad50-Nbs1 complex bound to ATPyS (composite structure) | | 分子名称: | DH domain-containing protein, Double-strand break repair protein, FHA domain-containing protein, ... | | 著者 | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | | 登録日 | 2022-05-03 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Mol.Cell, 83, 2023
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8BAH
 | | Human Mre11-Nbs1 complex | | 分子名称: | Double-strand break repair protein MRE11, MANGANESE (II) ION, Nibrin | | 著者 | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | | 登録日 | 2022-10-11 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (4.13 Å) | | 主引用文献 | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Mol.Cell, 83, 2023
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7ZR6
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7ZR5
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7T0Y
 | | The Ribosomal RNA Processing 1B Protein Phosphatase-1 Holoenzyme | | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, FLUORIDE ION, ... | | 著者 | Srivastava, G, Page, R, Peti, W. | | 登録日 | 2021-11-30 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The ribosomal RNA processing 1B:protein phosphatase 1 holoenzyme reveals non-canonical PP1 interaction motifs.
Cell Rep, 41, 2022
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7QM2
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7QFB
 | | Crystal structure of Protein Phosphatase 1 in complex with PP1-binding peptide from PTG | | 分子名称: | GLYCEROL, MANGANESE (II) ION, Protein phosphatase 1 regulatory subunit 3C, ... | | 著者 | Semrau, M.S, Storici, P, Lolli, G. | | 登録日 | 2021-12-05 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Molecular architecture of the glycogen- committed PP1/PTG holoenzyme.
Nat Commun, 13, 2022
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7SOY
 | | The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex | | 分子名称: | Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Protein phosphatase methylesterase 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | | 著者 | Li, Y, Balakrishnan, V.K, Rowse, M, Novikova, I.V, Xing, Y. | | 登録日 | 2021-11-01 | | 公開日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition.
Elife, 11, 2022
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8DZK
 | | Dbr1 in complex with 5-mer cleavage product | | 分子名称: | FE (II) ION, RNA (5'-R(P*(G46)P*UP*GP*UP*U)-3'), RNA lariat debranching enzyme, ... | | 著者 | Clark, N.E, Taylor, A.B. | | 登録日 | 2022-08-08 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product.
Biochemistry, 61, 2022
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7YZO
 | | Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and dsDNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (31-MER), MAGNESIUM ION, ... | | 著者 | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | | 登録日 | 2022-02-21 | | 公開日 | 2022-08-17 | | 最終更新日 | 2022-09-28 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
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7YZP
 | | Hairpin-bound state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and a DNA hairpin | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA hairpin (59-MER), MAGNESIUM ION, ... | | 著者 | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | | 登録日 | 2022-02-21 | | 公開日 | 2022-08-17 | | 最終更新日 | 2022-09-28 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
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7Z03
 | | Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and extended dsDNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (39-MER), MAGNESIUM ION, ... | | 著者 | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | | 登録日 | 2022-02-21 | | 公開日 | 2022-08-17 | | 最終更新日 | 2022-09-28 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
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7TXH
 | | Human MRas Q71R in complex with human Shoc2 LRR domain M173I and human PP1Ca | | 分子名称: | GLYCEROL, Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, ... | | 著者 | Hauseman, Z.J, Viscomi, J, Dhembi, A, Clark, K, King, D.A, Fodor, M. | | 登録日 | 2022-02-09 | | 公開日 | 2022-06-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Nature, 609, 2022
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7N6G
 | | C1 of central pair | | 分子名称: | CPC1, Calmodulin, DPY30, ... | | 著者 | Han, L, Zhang, K. | | 登録日 | 2021-06-08 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022
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7TVF
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7UPI
 | | Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex | | 分子名称: | CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, Leucine-rich repeat protein SHOC-2, ... | | 著者 | Fuller, J.R, Hajian, B, Lemke, C, Kwon, J, Bian, Y, Aguirre, A. | | 登録日 | 2022-04-15 | | 公開日 | 2022-05-04 | | 最終更新日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Nature, 609, 2022
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7SD0
 | | Cryo-EM structure of the SHOC2:PP1C:MRAS complex | | 分子名称: | Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, MANGANESE (II) ION, ... | | 著者 | Liau, N.P.D, Johnson, M.C, Hymowitz, S.G, Sudhamsu, J. | | 登録日 | 2021-09-29 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Structural basis for SHOC2 modulation of RAS signalling.
Nature, 609, 2022
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7SQC
 | | Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ... | | 著者 | Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R. | | 登録日 | 2021-11-05 | | 公開日 | 2022-04-13 | | 最終更新日 | 2022-06-08 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
Nat.Struct.Mol.Biol., 29, 2022
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