2Q7N
 
 | | Crystal structure of Leukemia inhibitory factor in complex with LIF receptor (domains 1-5) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Huyton, T, Zhang, J.G, Nicola, N.A, Garrett, T.P.J. | | Deposit date: | 2007-06-07 | | Release date: | 2007-07-31 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor.
Proc.Natl.Acad.Sci.USA, 104, 2007
|
|
1A22
 | | HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR | | Descriptor: | GROWTH HORMONE, GROWTH HORMONE RECEPTOR | | Authors: | De Vos, A.M, Ultsch, M. | | Deposit date: | 1998-01-15 | | Release date: | 1998-04-29 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
J.Mol.Biol., 277, 1998
|
|
1AXI
 | | STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE | | Descriptor: | GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION | | Authors: | Atwell, S, Ultsch, M, De Vos, A.M, Wells, J.A. | | Deposit date: | 1997-10-15 | | Release date: | 1998-01-28 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
|
|
4Y5Y
 | | Diabody 330 complex with EpoR | | Descriptor: | Erythropoietin receptor, GLYCEROL, diabody 330 VH domain, ... | | Authors: | Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C. | | Deposit date: | 2015-02-12 | | Release date: | 2015-03-18 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands.
Cell, 160, 2015
|
|
1BQU
 | | CYTOKYNE-BINDING REGION OF GP130 | | Descriptor: | GLYCEROL, PROTEIN (GP130), SULFATE ION | | Authors: | Bravo, J, Staunton, D, Heath, J.K, Jones, E.Y. | | Deposit date: | 1998-08-18 | | Release date: | 1998-08-26 | | Last modified: | 2022-12-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of a cytokine-binding region of gp130.
EMBO J., 17, 1998
|
|
4Y5X
 | | Diabody 305 complex with EpoR | | Descriptor: | CITRATE ANION, DI(HYDROXYETHYL)ETHER, Erythropoietin receptor, ... | | Authors: | Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C. | | Deposit date: | 2015-02-12 | | Release date: | 2015-03-18 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands.
Cell, 160, 2015
|
|
4YH7
 | | Crystal structure of PTPdelta ectodomain in complex with IL1RAPL1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 receptor accessory protein-like 1, ... | | Authors: | Yamagata, A, Fukai, S. | | Deposit date: | 2015-02-27 | | Release date: | 2015-05-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (4.4 Å) | | Cite: | Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation.
Nat Commun, 6, 2015
|
|
4Y5V
 | | Diabody 305 complex with EpoR | | Descriptor: | DI(HYDROXYETHYL)ETHER, Diabody 305 VL domain, Erythropoietin receptor, ... | | Authors: | Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C. | | Deposit date: | 2015-02-12 | | Release date: | 2015-04-29 | | Method: | X-RAY DIFFRACTION (2.604 Å) | | Cite: | Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands.
Cell, 160, 2015
|
|
4Y61
 | | Crystal structure of the complex between Slitrk2 LRR1 and PTP delta Ig1-Fn1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor-type tyrosine-protein phosphatase delta, SLIT and NTRK-like protein 2 | | Authors: | Yamgata, A, Sato, Y, Goto-Ito, S, Uemura, T, Maeda, A, Shiroshima, T, Yoshida, T, Fukai, S. | | Deposit date: | 2015-02-12 | | Release date: | 2015-06-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.358 Å) | | Cite: | Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion.
Sci Rep, 5, 2015
|
|
6MOH
 | | Dimeric DARPin C_R3 complex with EpoR | | Descriptor: | Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... | | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | | Deposit date: | 2018-10-04 | | Release date: | 2019-06-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
2V5Y
 | | Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU, SODIUM ION | | Authors: | Aricescu, A.R, Siebold, C, Choudhuri, K, Chang, V.T, Lu, W, Davis, S.J, van der Merwe, P.A, Jones, E.Y. | | Deposit date: | 2007-07-11 | | Release date: | 2007-09-11 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-Clamp Mechanism.
Science, 317, 2007
|
|
6MOI
 | | Dimeric DARPin C_angle_R5 complex with EpoR | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dimeric DARPing CCR5 (C_angle_R5), ... | | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | Deposit date: | 2018-10-04 | | Release date: | 2019-06-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.065 Å) | | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
4YFG
 | | Crystal structure of PTP delta meA3/meB minus variant Ig1-Fn1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor-type tyrosine-protein phosphatase delta | | Authors: | Yamagata, A, Fukai, S. | | Deposit date: | 2015-02-25 | | Release date: | 2015-05-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.491 Å) | | Cite: | Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation.
Nat Commun, 6, 2015
|
|
4YFD
 | | Crystal structure PTP delta Ig1-Fn2 in complex with IL-1RAcP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 receptor accessory protein, Receptor-type tyrosine-protein phosphatase delta | | Authors: | Yamagata, A, Fukai, S. | | Deposit date: | 2015-02-25 | | Release date: | 2015-05-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.253 Å) | | Cite: | Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation.
Nat Commun, 6, 2015
|
|
6MOK
 | | Dimeric DARPin A_distance_R7 complex with EpoR | | Descriptor: | Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor | | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | Deposit date: | 2018-10-04 | | Release date: | 2019-06-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (5.101 Å) | | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
6MOJ
 | | Dimeric DARPin A_angle_R5 complex with EpoR | | Descriptor: | D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... | | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | | Deposit date: | 2018-10-04 | | Release date: | 2019-06-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.431 Å) | | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
6MOE
 | | Monomeric DARPin E2 complex with EpoR | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ... | | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | | Deposit date: | 2018-10-04 | | Release date: | 2019-06-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.091 Å) | | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
6MOL
 | | Monoextended DARPin M_R12 complex with EpoR | | Descriptor: | Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) | | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | Deposit date: | 2018-10-04 | | Release date: | 2019-06-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.163 Å) | | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
6MOF
 | | Monomeric DARPin G2 complex with EpoR | | Descriptor: | 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin | | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | | Deposit date: | 2018-10-04 | | Release date: | 2019-06-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.894 Å) | | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
1CN4
 | |
6NAJ
 | |
2W1N
 | | cohesin and fibronectin type-III double module construct from the Clostridium perfringens glycoside hydrolase GH84C | | Descriptor: | ACETATE ION, O-GLCNACASE NAGJ | | Authors: | Ficko-Blean, E, Gregg, K.J, Adams, J.J, Hehemann, J.H, Czjzek, M, Smith, S.J, Boraston, A.B. | | Deposit date: | 2008-10-17 | | Release date: | 2009-02-03 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Portrait of an Enzyme: A Complete Structural Analysis of a Multi-Modular Beta-N-Acetylglucosaminidase from Clostridium Perfringens
J.Biol.Chem., 284, 2009
|
|
2X10
 | | Crystal structure of the complete EphA2 ectodomain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, EPHRIN TYPE-A RECEPTOR 2 | | Authors: | Seiradake, E, Harlos, K, Sutton, G, Aricescu, A.R, Jones, E.Y. | | Deposit date: | 2009-12-21 | | Release date: | 2010-03-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly
Nat.Struct.Mol.Biol., 17, 2010
|
|
2X11
 | | Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain | | Descriptor: | EPHRIN TYPE-A RECEPTOR 2, EPHRIN-A5 | | Authors: | Seiradake, E, Harlos, K, Sutton, G, Aricescu, A.R, Jones, E.Y. | | Deposit date: | 2009-12-21 | | Release date: | 2010-03-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (4.83 Å) | | Cite: | An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly
Nat.Struct.Mol.Biol., 17, 2010
|
|
1EER
 | |
