1A22

HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR

Summary for 1A22

• Entry DOI: 10.2210/pdb1a22/pdb
• Descriptor: GROWTH HORMONE, GROWTH HORMONE RECEPTOR (3 entities in total)
• Functional Keywords: complex (hormone-receptor), pituitary, hormone, complex (hormone-receptor) complex, complex (hormone/receptor)
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01241; Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Growth hormone-binding protein: Secreted: P10912
• Total number of polymer chains: 2
• Total formula weight: 49661.91

Authors

De Vos, A.M.,Ultsch, M. (deposition date: 1998-01-15, release date: 1998-04-29, Last modification date: 2023-08-02)

• Primary citation: Clackson, T.,Ultsch, M.H.,Wells, J.A.,de Vos, A.M.; Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.; J.Mol.Biol., 277:1111-1128, 1998; PubMed: 9571026; DOI: 10.1006/jmbi.1998.1669

Experimental method

X-RAY DIFFRACTION (2.6 Å)