Crystal structure of the complete EphA2 ectodomain

Summary for 2X10

Related1MQB 2X11
DescriptorEPHRIN TYPE-A RECEPTOR 2, CHLORIDE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywordstransferase, angiogenesis, kinase, cataract, receptor, apoptosis, glycoprotein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight60678.61
Seiradake, E.,Harlos, K.,Sutton, G.,Aricescu, A.R.,Jones, E.Y. (deposition date: 2009-12-21, release date: 2010-03-16, Last modification date: 2020-07-29)
Primary citation
Seiradake, E.,Harlos, K.,Sutton, G.,Aricescu, A.R.,Jones, E.Y.
An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly
Nat.Struct.Mol.Biol., 17:398-, 2010
PubMed: 20228801 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB.1782
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.28916 0.8% 5.4% 0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-23