2X11

Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain

Summary for 2X11

Entry DOI	10.2210/pdb2x11/pdb
Related	1MQB 2X10
Descriptor	EPHRIN TYPE-A RECEPTOR 2, EPHRIN-A5 (2 entities in total)
Functional Keywords	receptor-signaling protein complex, developmental protein, signaling platform, kinase, transferase, neurogenesis, receptor, cataract, apoptosis, erythropoietin-producing hepatocellular carcinoma, angiogenesis, signaling protein, receptor/signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	80261.54
Authors	Seiradake, E.,Harlos, K.,Sutton, G.,Aricescu, A.R.,Jones, E.Y. (deposition date: 2009-12-21, release date: 2010-03-16, Last modification date: 2023-12-20)
Primary citation	Seiradake, E.,Harlos, K.,Sutton, G.,Aricescu, A.R.,Jones, E.Y. An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly Nat.Struct.Mol.Biol., 17:398-, 2010 Cited by PubMed: 20228801 DOI: 10.1038/NSMB.1782 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.83 Å)

Structure validation