PDB: 1372 resultsInfo pagesStatus searchChemie searchBIRD

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6UZK	Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi6 Descriptor: 2-hydroxy-6-methoxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... Authors: Gingras, A.R. Deposit date: 2019-11-15 Release date: 2020-11-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.924 Å) Cite: Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. Faseb Bioadv, 3, 2021
6V9F	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods Descriptor: 1-[(4-chlorophenyl)methyl]-1H-benzimidazol-2-amine, FORMIC ACID, GLYCEROL, ... Authors: Phan, J, Fesik, S.W. Deposit date: 2019-12-13 Release date: 2020-08-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.849 Å) Cite: Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
6V9L	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods Descriptor: 4-(3-chloro-4-fluorophenoxy)benzene-1-sulfonamide, ACETATE ION, FORMIC ACID, ... Authors: Phan, J, Fesik, S.W. Deposit date: 2019-12-13 Release date: 2020-08-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.698 Å) Cite: Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
6V9O	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods Descriptor: 3-(phenylsulfonyl)benzene-1-sulfonamide, FORMIC ACID, GLYCEROL, ... Authors: Phan, J, Fesik, S.W. Deposit date: 2019-12-13 Release date: 2020-12-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.799 Å) Cite: Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods To Be Published
3Q3J	Crystal structure of plexin A2 RBD in complex with Rnd1 Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-A2, ... Authors: Wang, H, Tempel, W, Tong, Y, Guan, X, Shen, L, Buren, L, Zhang, N, Wernimont, A.K, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) Deposit date: 2010-12-21 Release date: 2011-01-12 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.971 Å) Cite: Crystal structure of plexin A2 RBD in complex with Rnd1 to be published
4F38	Crystal structure of geranylgeranylated RhoA in complex with RhoGDI in its active GPPNHP-bound form Descriptor: GERAN-8-YL GERAN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Guo, Z, Tnimov, Z, Alexandrov, K. Deposit date: 2012-05-09 Release date: 2012-05-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Quantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDI. J.Biol.Chem., 287, 2012
4FMC	EspG-Rab1 complex Descriptor: ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Shao, F, Zhu, Y. Deposit date: 2012-06-16 Release date: 2012-09-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses. Cell(Cambridge,Mass.), 150, 2012
6W4F	NMR-driven structure of KRAS4B-GDP homodimer on a lipid bilayer nanodisc Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ... Authors: Lee, K, Fang, Z, Enomoto, M, Gasmi-Seabrook, G.M, Zheng, L, Marshall, C.B, Ikura, M. Deposit date: 2020-03-10 Release date: 2020-04-29 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement. Angew.Chem.Int.Ed.Engl., 59, 2020
6W4E	NMR-driven structure of KRAS4B-GTP homodimer on a lipid bilayer nanodisc Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, ... Authors: Lee, K, Fang, Z, Enomoto, M, Gasmi-Seabrook, G.M, Zheng, L, Marshall, C.B, Ikura, M. Deposit date: 2020-03-10 Release date: 2020-04-15 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement. Angew.Chem.Int.Ed.Engl., 59, 2020
4G0N	Crystal Structure of wt H-Ras-GppNHp bound to the RBD of Raf Kinase Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, ACETATE ION, CALCIUM ION, ... Authors: Fetics, S.K, Kearney, B.M, Buhrman, G, Mattos, C. Deposit date: 2012-07-09 Release date: 2013-07-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD. Structure, 23, 2015
6X2W	Crystal Structure of PKINES peptide bound to CRM1(E571K) Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Baumhardt, J.M. Deposit date: 2020-05-21 Release date: 2020-07-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.001 Å) Cite: Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2U	Crystal Structure of PKINES peptide bound to CRM1 Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Baumhardt, J.M. Deposit date: 2020-05-21 Release date: 2020-07-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
4GMX	Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-08-16 Release date: 2012-10-17 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood, 120, 2012
4G01	ARA7-GDP-Ca2+/VPS9a Descriptor: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Ras-related protein RABF2b, ... Authors: Ihara, K. Deposit date: 2012-07-09 Release date: 2013-02-27 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Direct metal recognition by guanine nucleotide-exchange factor in the initial step of the exchange reaction Acta Crystallogr.,Sect.D, 69, 2013
6WCW	Structure of human Rubicon RH domain in complex with GTP-bound Rab7 Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7a, ... Authors: Bhargava, H.K, Byck, J.M, Farrell, D.P, Anishchenko, I, DiMaio, F, Im, Y.J, Hurley, J.H. Deposit date: 2020-03-31 Release date: 2020-07-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex. Proc.Natl.Acad.Sci.USA, 117, 2020
4HAW	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548A)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HB4	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(537DLTVK541/GLCEQ)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
6X2S	Crystal Structure of Mek1(NQ)NES peptide bound to CRM Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... Authors: Baumhardt, J.M. Deposit date: 2020-05-20 Release date: 2020-07-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.496 Å) Cite: Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2P	Crystal Structure of the Mek1NES peptide bound to CRM1 Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... Authors: Baumhardt, J.M. Deposit date: 2020-05-20 Release date: 2020-07-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.401 Å) Cite: Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2V	Crystal Structure of PKI(DE)NES peptide bound to CRM1 Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Baumhardt, J.M. Deposit date: 2020-05-21 Release date: 2020-07-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.822 Å) Cite: Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
3QBT	Crystal structure of OCRL1 540-678 in complex with Rab8a:GppNHp Descriptor: Inositol polyphosphate 5-phosphatase OCRL-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Hou, X, Hagemann, N, Schoebel, S, Blankenfeldt, W, Goody, R.S, Erdmann, K.S, Itzen, A. Deposit date: 2011-01-14 Release date: 2011-03-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. Embo J., 30, 2011
6X2O	Crystal Structure of unliganded CRM1(E571K)-Ran-RanBP1 Descriptor: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... Authors: Baumhardt, J.M. Deposit date: 2020-05-20 Release date: 2020-07-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.551 Å) Cite: Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2M	Crystal Structure of unliganded CRM1-Ran-RanBP1 Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Baumhardt, J.M. Deposit date: 2020-05-20 Release date: 2020-07-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.351 Å) Cite: Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
4FMB	VirA-Rab1 complex structure Descriptor: ALUMINUM FLUORIDE, Cysteine protease-like virA, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Shao, F, Zhu, Y. Deposit date: 2012-06-16 Release date: 2012-09-05 Last modified: 2012-10-03 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses. Cell(Cambridge,Mass.), 150, 2012
6VJJ	Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Tran, T.H, Dharmaiah, S, Simanshu, D.K. Deposit date: 2020-01-16 Release date: 2020-11-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.4 Å) Cite: KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021

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