6WCW

Structure of human Rubicon RH domain in complex with GTP-bound Rab7

Summary for 6WCW

• Entry DOI: 10.2210/pdb6wcw/pdb
• Descriptor: Ras-related protein Rab-7a, Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, GUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: autophagy, rab, gtpase, aging, zinc finger, g protein, metal binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 51191.26

Authors

Bhargava, H.K.,Byck, J.M.,Farrell, D.P.,Anishchenko, I.,DiMaio, F.,Im, Y.J.,Hurley, J.H. (deposition date: 2020-03-31, release date: 2020-07-01, Last modification date: 2023-10-18)

• Primary citation: Bhargava, H.K.,Tabata, K.,Byck, J.M.,Hamasaki, M.,Farrell, D.P.,Anishchenko, I.,DiMaio, F.,Im, Y.J.,Yoshimori, T.,Hurley, J.H.; Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.; Proc.Natl.Acad.Sci.USA, 117:17003-17010, 2020; PubMed: 32632011; DOI: 10.1073/pnas.2008030117

Experimental method

X-RAY DIFFRACTION (2.8 Å)