4HB4

Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(537DLTVK541/GLCEQ)-Ran-RanBP1

Summary for 4HB4

Related4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3
DescriptorGTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (10 entities in total)
Functional Keywordsheat repeat, nuclear export, ran-ranbp1, lmb, leptomycin b, protein transport-antibiotic complex, protein transport/antibiotic
Biological sourceHomo sapiens (human)
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Cellular locationNucleus  P62826 P30822
Cytoplasm P41920
Total number of polymer chains3
Total molecular weight159669.96
Authors
Sun, Q.,Chook, Y.M. (deposition date: 2012-09-27, release date: 2013-01-09, Last modification date: 2017-07-26)
Primary citation
Sun, Q.,Carrasco, Y.P.,Hu, Y.,Guo, X.,Mirzaei, H.,Macmillan, J.,Chook, Y.M.
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110:1303-1308, 2013
PubMed: 23297231 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1217203110
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.05 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24250.1%2.1%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4hb4
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Molmil generated image of 4hb4
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Molmil generated image of 4hb4
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