4GMX

Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1

Summary for 4GMX

Entry DOI	10.2210/pdb4gmx/pdb
Related	4GPT
Descriptor	GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (10 entities in total)
Functional Keywords	heat repeat, protein export, crm1, kpt185, nuclear, protein transport-inhibitor complex, protein transport/inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P62826 P30822 Cytoplasm: P41920
Total number of polymer chains	3
Total formula weight	163913.20
Authors	Sun, Q.,Chook, Y.M. (deposition date: 2012-08-16, release date: 2012-10-17, Last modification date: 2012-12-12)
Primary citation	Lapalombella, R.,Sun, Q.,Williams, K.,Tangeman, L.,Jha, S.,Zhong, Y.,Goettl, V.,Mahoney, E.,Berglund, C.,Gupta, S.,Farmer, A.,Mani, R.,Johnson, A.J.,Lucas, D.,Mo, X.,Daelemans, D.,Sandanayaka, V.,Shechter, S.,McCauley, D.,Shacham, S.,Kauffman, M.,Chook, Y.M.,Byrd, J.C. Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood, 120:4621-4634, 2012 Cited by PubMed: 23034282 DOI: 10.1182/blood-2012-05-429506 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation