3I89
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![BU of 3i89 by Molmil](/molmil-images/mine/3i89) | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR22 | Descriptor: | DNA damage-binding protein 1, WD repeat-containing protein 22 | Authors: | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | Deposit date: | 2009-07-09 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
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3IK7
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![BU of 3ik7 by Molmil](/molmil-images/mine/3ik7) | Human glutathione transferase a4-4 with GSDHN | Descriptor: | (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid, Glutathione S-transferase A4, SULFATE ION | Authors: | Balogh, L.M, Le Trong, I, Atkins, W.M, Stenkamp, R.E. | Deposit date: | 2009-08-05 | Release date: | 2010-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. Biochemistry, 49, 2010
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2RMW
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![BU of 2rmw by Molmil](/molmil-images/mine/2rmw) | |
3EVQ
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![BU of 3evq by Molmil](/molmil-images/mine/3evq) | |
2RNL
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![BU of 2rnl by Molmil](/molmil-images/mine/2rnl) | Solution structure of the EGF-like domain from human Amphiregulin | Descriptor: | Amphiregulin | Authors: | Qin, X, Hayashi, F, Terada, T, Shirouzu, M, Watanabe, S, Kigawa, T, Yabuta, N, Nojima, H, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2008-01-11 | Release date: | 2009-01-20 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Solution structure of the EGF-like domain from human Amphiregulin To be Published
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3EPA
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![BU of 3epa by Molmil](/molmil-images/mine/3epa) | Human AdoMetDC E178Q mutant complexed with putrescine | Descriptor: | 1,4-DIAMINOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PYRUVIC ACID, ... | Authors: | Bale, S, Lopez, M.M, Makhatadze, G.I, Fang, Q, Pegg, A.E, Ealick, S.E. | Deposit date: | 2008-09-29 | Release date: | 2008-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase. Biochemistry, 47, 2008
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3EP3
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![BU of 3ep3 by Molmil](/molmil-images/mine/3ep3) | Human AdoMetDC D174N mutant with no putrescine bound | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PYRUVIC ACID, S-adenosylmethionine decarboxylase alpha chain, ... | Authors: | Bale, S, Lopez, M.M, Makhatadze, G.I, Fang, Q, Pegg, A.E, Ealick, S.E. | Deposit date: | 2008-09-29 | Release date: | 2008-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase. Biochemistry, 47, 2008
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2RNX
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![BU of 2rnx by Molmil](/molmil-images/mine/2rnx) | The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the HUman Transcriptional Co-Activators PCAF and CBP | Descriptor: | Histone H3, Histone acetyltransferase PCAF | Authors: | Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M. | Deposit date: | 2008-02-03 | Release date: | 2008-05-06 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300 Structure, 16, 2008
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2RLL
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![BU of 2rll by Molmil](/molmil-images/mine/2rll) | CCR5 Nt(7-15) | Descriptor: | 9-mer from C-C chemokine receptor type 5 | Authors: | Bewley, C.A, Lam, S.N. | Deposit date: | 2007-07-21 | Release date: | 2007-09-25 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4 Science, 317, 2007
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3IMY
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3EXO
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![BU of 3exo by Molmil](/molmil-images/mine/3exo) | Crystal structure of BACE1 bound to inhibitor | Descriptor: | Beta-secretase 1, GLYCEROL, N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide, ... | Authors: | Allison, T.J. | Deposit date: | 2008-10-16 | Release date: | 2009-02-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement. Bioorg.Med.Chem.Lett., 19, 2009
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3IGG
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![BU of 3igg by Molmil](/molmil-images/mine/3igg) | Novel CDK-5 inhibitors - crystal structure of inhibitor EFQ with CDK-2 | Descriptor: | Cell division protein kinase 2, N-[1-(cis-3-hydroxycyclobutyl)-1H-imidazol-4-yl]-2-(4-methoxyphenyl)acetamide | Authors: | Pandit, J. | Deposit date: | 2009-07-27 | Release date: | 2009-09-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease. Bioorg.Med.Chem.Lett., 19, 2009
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2RQ8
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![BU of 2rq8 by Molmil](/molmil-images/mine/2rq8) | Solution NMR structure of titin I27 domain mutant | Descriptor: | Titin | Authors: | Yagawa, K, Oguro, T, Momose, T, Kawano, S, Sato, T, Endo, T. | Deposit date: | 2009-03-05 | Release date: | 2010-02-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural basis for unfolding pathway-dependent stability of proteins: Vectorial unfolding vs. global unfolding Protein Sci., 2010
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2RPC
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3FFC
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![BU of 3ffc by Molmil](/molmil-images/mine/3ffc) | Crystal Structure of CF34 TCR in complex with HLA-B8/FLR | Descriptor: | Beta-2-microglobulin, CADMIUM ION, CF34 alpha chain, ... | Authors: | Gras, S, Burrows, S.R, Kjer-Nielsen, L, Clements, C.S, Liu, Y.C, Sullivan, L.C, Brooks, A.G, Purcell, A.W, McCluskey, J, Rossjohn, J. | Deposit date: | 2008-12-03 | Release date: | 2009-01-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The shaping of T cell receptor recognition by self-tolerance. Immunity, 30, 2009
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3ISB
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![BU of 3isb by Molmil](/molmil-images/mine/3isb) | Binary complex of human DNA polymerase beta with a gapped DNA | Descriptor: | 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | Authors: | Beard, W.A, Shock, D.D, Batra, V.K, Pedersen, L.C, Wilson, S.H. | Deposit date: | 2009-08-25 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". J.Biol.Chem., 284, 2009
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2RLO
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![BU of 2rlo by Molmil](/molmil-images/mine/2rlo) | Split PH domain of PI3-kinase enhancer | Descriptor: | Centaurin-gamma 1 | Authors: | Wen, W, Zhang, M. | Deposit date: | 2007-07-21 | Release date: | 2008-04-29 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase J.Mol.Biol., 378, 2008
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3IW7
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![BU of 3iw7 by Molmil](/molmil-images/mine/3iw7) | Human p38 MAP Kinase in Complex with an Imidazo-pyridine | Descriptor: | 2-({4-[(4-benzylpiperidin-1-yl)carbonyl]benzyl}sulfanyl)-3H-imidazo[4,5-c]pyridine, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | Authors: | Gruetter, C, Simard, J.R, Rauh, D. | Deposit date: | 2009-09-02 | Release date: | 2009-11-17 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha J.Am.Chem.Soc., 131, 2009
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2ROP
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![BU of 2rop by Molmil](/molmil-images/mine/2rop) | Solution structure of domains 3 and 4 of human ATP7B | Descriptor: | Copper-transporting ATPase 2 | Authors: | Banci, L, Bertini, I, Cantini, F, Rosenzweig, A.C, Yatsunyk, L.A. | Deposit date: | 2008-04-04 | Release date: | 2008-10-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Metal binding domains 3 and 4 of the Wilson disease protein: solution structure and interaction with the copper(I) chaperone HAH1 Biochemistry, 47, 2008
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2RQB
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![BU of 2rqb by Molmil](/molmil-images/mine/2rqb) | Solution structure of MDA5 CTD | Descriptor: | Interferon-induced helicase C domain-containing protein 1, ZINC ION | Authors: | Takahasi, K, Kumeta, H, Tsuduki, N, Narita, R, Shigemoto, T, Hirai, R, Yoneyama, M, Horiuchi, M, Ogura, K, Fujita, T, Fuyuhiko, I. | Deposit date: | 2009-03-17 | Release date: | 2009-05-05 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains: IDENTIFICATION OF THE RNA RECOGNITION LOOP IN RIG-I-LIKE RECEPTORS J.Biol.Chem., 284, 2009
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3I81
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![BU of 3i81 by Molmil](/molmil-images/mine/3i81) | Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807 [1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-L-prolinamide] | Descriptor: | 1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-proli namide, Insulin-like growth factor 1 receptor | Authors: | Sack, J.S. | Deposit date: | 2009-07-09 | Release date: | 2009-12-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J.Med.Chem., 52, 2009
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3I8C
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![BU of 3i8c by Molmil](/molmil-images/mine/3i8c) | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR21A | Descriptor: | DNA damage-binding protein 1, WD repeat-containing protein 21A | Authors: | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | Deposit date: | 2009-07-09 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
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3IA6
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2RMJ
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![BU of 2rmj by Molmil](/molmil-images/mine/2rmj) | Solution structure of RIG-I C-terminal domain | Descriptor: | Probable ATP-dependent RNA helicase DDX58 | Authors: | Takahasi, K, Yoneyama, M, Nihishori, T, Hirai, R, Narita, R, Gale Jr, M, Fujita, T, Inagaki, F. | Deposit date: | 2007-10-23 | Release date: | 2008-03-25 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses Mol.Cell, 29, 2008
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3IE3
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![BU of 3ie3 by Molmil](/molmil-images/mine/3ie3) | Structural basis for the binding of the anti-cancer compound 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) to human glutathione S-transferases | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]hexan-1-ol, GLUTATHIONE, ... | Authors: | Federici, L, Lo Sterzo, C, Di Matteo, A, Scaloni, F, Federici, G, Caccuri, A.M. | Deposit date: | 2009-07-22 | Release date: | 2009-10-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases Cancer Res., 69, 2009
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