3IA6

X-ray Crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a PPAR gamma/alpha dual agonist

Summary for 3IA6

Entry DOI	10.2210/pdb3ia6/pdb
Related	2Q8S
Descriptor	Peroxisome proliferator-activated receptor gamma, (2S)-3-{4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl}-2-(2H-1,2,3-triazol-2-yl)propanoic acid (3 entities in total)
Functional Keywords	protein-ligand complex, dual specificity, inhibitor, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	62826.99
Authors	Ohren, J.F. (deposition date: 2009-07-13, release date: 2009-10-13, Last modification date: 2023-09-06)
Primary citation	Casimiro-Garcia, A.,Bigge, C.F.,Davis, J.A.,Padalino, T.,Pulaski, J.,Ohren, J.F.,McConnell, P.,Kane, C.D.,Royer, L.J.,Stevens, K.A.,Auerbach, B.,Collard, W.,McGregor, C.,Song, K. Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists. Bioorg.Med.Chem., 17:7113-7125, 2009 Cited by PubMed: 19783444 DOI: 10.1016/j.bmc.2009.09.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.31 Å)

Structure validation