2Q8S
X-ray Crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a PPAR gamma/alpha dual agonist
Summary for 2Q8S
Entry DOI | 10.2210/pdb2q8s/pdb |
Related | 2PRG |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2S)-3-{4-[3-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)PROPYL]PHENYL}-2-(1H-PYRROL-1-YL)PROPANOIC ACID (3 entities in total) |
Functional Keywords | ligand-bound complex, hormone receptor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 62408.54 |
Authors | Ohren, J.F. (deposition date: 2007-06-11, release date: 2008-10-14, Last modification date: 2023-08-30) |
Primary citation | Casimiro-Garcia, A.,Bigge, C.F.,Davis, J.A.,Padalino, T.,Pulaski, J.,Ohren, J.F.,McConnell, P.,Kane, C.D.,Royer, L.J.,Stevens, K.A.,Auerbach, B.J.,Collard, W.T.,McGregor, C.,Fakhoury, S.A.,Schaum, R.P.,Zhou, H. Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies. Bioorg.Med.Chem., 16:4883-4907, 2008 Cited by PubMed: 18394907DOI: 10.1016/j.bmc.2008.03.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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