2RQB

Solution structure of MDA5 CTD

Summary for 2RQB

Entry DOI	10.2210/pdb2rqb/pdb
Descriptor	Interferon-induced helicase C domain-containing protein 1, ZINC ION (2 entities in total)
Functional Keywords	rna binding protein, hydrolase, alternative splicing, antiviral defense, atp-binding, cytoplasm, diabetes mellitus, helicase, host-virus interaction, immune response, innate immunity, nucleotide-binding, nucleus, phosphoprotein, polymorphism, rna-binding
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q9BYX4
Total number of polymer chains	1
Total formula weight	15568.51
Authors	Takahasi, K.,Kumeta, H.,Tsuduki, N.,Narita, R.,Shigemoto, T.,Hirai, R.,Yoneyama, M.,Horiuchi, M.,Ogura, K.,Fujita, T.,Fuyuhiko, I. (deposition date: 2009-03-17, release date: 2009-05-05, Last modification date: 2022-03-16)
Primary citation	Takahasi, K.,Kumeta, H.,Tsuduki, N.,Narita, R.,Shigemoto, T.,Hirai, R.,Yoneyama, M.,Horiuchi, M.,Ogura, K.,Fujita, T.,Inagaki, F. Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains: IDENTIFICATION OF THE RNA RECOGNITION LOOP IN RIG-I-LIKE RECEPTORS J.Biol.Chem., 284:17465-17474, 2009 Cited by PubMed: 19380577 DOI: 10.1074/jbc.M109.007179 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation