3IK7

Human glutathione transferase a4-4 with GSDHN

Summary for 3IK7

• Entry DOI: 10.2210/pdb3ik7/pdb
• Related: 3IK9
• Descriptor: Glutathione S-transferase A4, (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: human gst a4-4, enzyme, transferase, cytoplasm, polymorphism
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: O15217
• Total number of polymer chains: 4
• Total formula weight: 104910.69

Authors

Balogh, L.M.,Le Trong, I.,Atkins, W.M.,Stenkamp, R.E. (deposition date: 2009-08-05, release date: 2010-06-23, Last modification date: 2023-09-06)

• Primary citation: Balogh, L.M.,Le Trong, I.,Kripps, K.A.,Shireman, L.M.,Stenkamp, R.E.,Zhang, W.,Mannervik, B.,Atkins, W.M.; Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.; Biochemistry, 49:1541-1548, 2010; PubMed: 20085333; DOI: 10.1021/bi902038u

Experimental method

X-RAY DIFFRACTION (1.97 Å)