3IK7
Human glutathione transferase a4-4 with GSDHN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| C | 0004364 | molecular_function | glutathione transferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006749 | biological_process | glutathione metabolic process |
| C | 0006805 | biological_process | xenobiotic metabolic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| D | 0004364 | molecular_function | glutathione transferase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006749 | biological_process | glutathione metabolic process |
| D | 0006805 | biological_process | xenobiotic metabolic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE BOB A 501 |
| Chain | Residue |
| A | TYR9 |
| A | PHE220 |
| A | HOH6007 |
| A | HOH6150 |
| A | HOH6210 |
| B | ASP101 |
| B | ARG131 |
| A | ARG15 |
| A | GLN54 |
| A | VAL55 |
| A | PRO56 |
| A | GLN67 |
| A | THR68 |
| A | PHE111 |
| A | TYR212 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE BOB B 502 |
| Chain | Residue |
| A | ASP101 |
| A | ARG131 |
| B | TYR9 |
| B | GLY14 |
| B | ARG15 |
| B | GLN45 |
| B | GLN54 |
| B | VAL55 |
| B | GLN67 |
| B | THR68 |
| B | PHE111 |
| B | TYR212 |
| B | PHE220 |
| B | HOH6008 |
| B | HOH6125 |
| B | HOH6161 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE BOB C 503 |
| Chain | Residue |
| C | TYR9 |
| C | GLY14 |
| C | GLN45 |
| C | GLN54 |
| C | VAL55 |
| C | GLN67 |
| C | THR68 |
| C | TYR212 |
| C | PHE220 |
| C | HOH6131 |
| D | ASP101 |
| D | ARG131 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE BOB D 504 |
| Chain | Residue |
| C | ASP101 |
| C | ARG131 |
| D | TYR9 |
| D | GLY14 |
| D | ARG15 |
| D | GLN54 |
| D | VAL55 |
| D | GLN67 |
| D | THR68 |
| D | MET108 |
| D | TYR212 |
| D | TYR217 |
| D | PHE220 |
| D | HOH6104 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 551 |
| Chain | Residue |
| C | LYS43 |
| D | THR37 |
| D | LYS38 |
| D | GLU39 |
| D | ASN218 |
| D | ARG221 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 320 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 492 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P13745","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P30711","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
