3IGG
Novel CDK-5 inhibitors - crystal structure of inhibitor EFQ with CDK-2
Summary for 3IGG
Entry DOI | 10.2210/pdb3igg/pdb |
Related | 3IG7 |
Descriptor | Cell division protein kinase 2, N-[1-(cis-3-hydroxycyclobutyl)-1H-imidazol-4-yl]-2-(4-methoxyphenyl)acetamide (3 entities in total) |
Functional Keywords | protein kinase, transferase, serine/threonine protein kinase, inhibitor, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34303.87 |
Authors | Pandit, J. (deposition date: 2009-07-27, release date: 2009-09-08, Last modification date: 2011-07-13) |
Primary citation | Helal, C.J.,Kang, Z.,Lucas, J.C.,Gant, T.,Ahlijanian, M.K.,Schachter, J.B.,Richter, K.E.,Cook, J.M.,Menniti, F.S.,Kelly, K.,Mente, S.,Pandit, J.,Hosea, N. Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease. Bioorg.Med.Chem.Lett., 19:5703-5707, 2009 Cited by PubMed: 19700321DOI: 10.1016/j.bmcl.2009.08.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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