Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR22

Summary for 3I89

Related2B5M 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I8C 3I8E
DescriptorDNA damage-binding protein 1, WD repeat-containing protein 22 (2 entities in total)
Functional Keywordsddb1, wdr22, dcaf5, h-box motif, cytoplasm, dna damage, dna repair, dna-binding, host-virus interaction, nucleus, phosphoprotein, polymorphism, ubl conjugation, ubl conjugation pathway, alternative splicing, wd repeat, protein binding
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q16531
Total number of polymer chains2
Total molecular weight128758.31
Li, T.,Robert, E.I.,Breugel, P.C.V.,Strubin, M.,Zheng, N. (deposition date: 2009-07-09, release date: 2009-12-08, Last modification date: 2011-07-13)
Primary citation
Li, T.,Robert, E.I.,van Breugel, P.C.,Strubin, M.,Zheng, N.
A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.
Nat.Struct.Mol.Biol., 17:105-111, 2010
PubMed: 19966799 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.1719
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.263397.2%14.6%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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