3EXO

Crystal structure of BACE1 bound to inhibitor

Summary for 3EXO

Entry DOI	10.2210/pdb3exo/pdb
Descriptor	Beta-secretase 1, SULFATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	beta secretase, bace 1, aspartyl protease, glycoprotein, hydrolase, membrane, protease, transmembrane, zymogen
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	1
Total formula weight	46729.34
Authors	Allison, T.J. (deposition date: 2008-10-16, release date: 2009-02-03, Last modification date: 2023-12-27)
Primary citation	Steele, T.G.,Hills, I.D.,Nomland, A.A.,de Leon, P.,Allison, T.,McGaughey, G.,Colussi, D.,Tugusheva, K.,Haugabook, S.J.,Espeseth, A.S.,Zuck, P.,Graham, S.L.,Stachel, S.J. Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement. Bioorg.Med.Chem.Lett., 19:17-20, 2009 Cited by PubMed: 19036583 DOI: 10.1016/j.bmcl.2008.11.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation