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3DSH
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BU of 3dsh by Molmil
Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain
Descriptor: Interferon regulatory factor 5
Authors:Chen, W, Lam, S.S, Srinath, H, Jiang, Z, Correia, J.J, Schiffer, C, Fitzgerald, K.A, Lin, K, Royer Jr, W.E.
Deposit date:2008-07-12
Release date:2008-10-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Nat.Struct.Mol.Biol., 15, 2008
5KVD
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BU of 5kvd by Molmil
Zika specific antibody, ZV-2, bound to ZIKA envelope DIII
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SODIUM ION, ...
Authors:Zhao, H, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-07-14
Release date:2016-08-03
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis of Zika Virus-Specific Antibody Protection.
Cell, 166, 2016
8T5K
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BU of 8t5k by Molmil
Crystal structure of STING CTD in complex with BDW-OH
Descriptor: Stimulator of interferon genes protein, {[(4S)-8,9-dimethylthieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3-yl]sulfanyl}acetic acid
Authors:Li, Y, Li, P, Sun, D.
Deposit date:2023-06-13
Release date:2023-07-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants.
Biorxiv, 2023
8T5L
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BU of 8t5l by Molmil
Crystal structure of STING CTD in complex with 2'3'-cGAMP
Descriptor: Stimulator of interferon genes protein, cGAMP
Authors:Li, Y, Li, P, Sun, D.
Deposit date:2023-06-13
Release date:2023-07-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants.
Biorxiv, 2023
6MYD
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BU of 6myd by Molmil
Structure of zebrafish TRAF6 in complex with STING CTT
Descriptor: STING CTT, Transmembrane protein 173, SULFATE ION, ...
Authors:de Oliveira Mann, C.C, Orzalli, M.H, King, D.S, Kagan, J.C, Lee, A.S.Y, Kranzusch, P.J.
Deposit date:2018-11-01
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-kappa B Signaling Adaptation.
Cell Rep, 27, 2019
6NT9
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BU of 6nt9 by Molmil
Cryo-EM structure of the complex between human TBK1 and chicken STING
Descriptor: Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein
Authors:Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of STING binding with and phosphorylation by TBK1.
Nature, 567, 2019
4MKP
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BU of 4mkp by Molmil
Crystal structure of human cGAS apo form
Descriptor: Cyclic GMP-AMP synthase, ZINC ION
Authors:Kato, K, Ishii, R, Ishitani, R, Nureki, O.
Deposit date:2013-09-05
Release date:2013-10-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.953 Å)
Cite:Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS
Plos One, 8, 2013
7OB3
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BU of 7ob3 by Molmil
hSTING in complex with 3',3'-c-di-araAMP
Descriptor: 3',3'-c-di-araAMP, Stimulator of interferon genes protein
Authors:Smola, M, Boura, E.
Deposit date:2021-04-20
Release date:2022-05-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations
Biochemistry, 2021
6YWA
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BU of 6ywa by Molmil
Human REF STING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)]
Descriptor: 3',3'-c-[2'FdAMP-2'FdAM(PS)], GLYCEROL, Stimulator of interferon genes protein
Authors:Boura, E, Smola, M.
Deposit date:2020-04-29
Release date:2021-05-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.311 Å)
Cite:Human REF STING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)]
To Be Published
4XR8
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BU of 4xr8 by Molmil
Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ...
Authors:Martinez-Zapien, D, Ruiz, F.X, Mitschler, A, Podjarny, A, Trave, G, Zanier, K.
Deposit date:2015-01-20
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
Nature, 529, 2016
6DNK
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BU of 6dnk by Molmil
Human Stimulator of Interferon Genes
Descriptor: Stimulator of interferon genes protein, cGAMP
Authors:Fernandez, D, Li, L, Ergun, S.L.
Deposit date:2018-06-06
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Cell, 178, 2019
2K36
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BU of 2k36 by Molmil
Structure ensemble Backbone and side-chain 1H, 13C, and 15N Chemical Shift Assignments, 1H-15N RDCs and 1H-1H nOe restraints for protein K7 from the Vaccinia virus
Descriptor: Protein K7
Authors:Kalverda, A.P, Thompson, G.S, Vogel, A, Schr der, M, Bowie, A.G, Khan, A.R, Homans, S.W.
Deposit date:2008-04-22
Release date:2008-10-28
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3.
J.Mol.Biol., 385, 2009
6GYR
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BU of 6gyr by Molmil
Transcription factor dimerization activates the p300 acetyltransferase
Descriptor: Histone acetyltransferase p300, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate
Authors:Panne, D, Ortega, E.
Deposit date:2018-07-01
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Transcription factor dimerization activates the p300 acetyltransferase.
Nature, 562, 2018
3JRV
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BU of 3jrv by Molmil
Structure of poxvirus K7 protein in complex with RNA helicase DDX3
Descriptor: ATP-dependent RNA helicase DDX3X, Protein K7
Authors:Oda, S, Khan, R.A.
Deposit date:2009-09-09
Release date:2009-11-10
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7
Structure, 17, 2009
6GYT
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BU of 6gyt by Molmil
Transcription factor dimerization activates the p300 acetyltransferase
Descriptor: Histone H4, Histone acetyltransferase p300, ZINC ION
Authors:Panne, D, Ortega, E.
Deposit date:2018-07-01
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Transcription factor dimerization activates the p300 acetyltransferase.
Nature, 562, 2018
7F60
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BU of 7f60 by Molmil
Crystal structure of auxiliary protein in complex with human nuclear protein
Descriptor: Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor
Authors:Gao, X, Cui, S.
Deposit date:2021-06-23
Release date:2022-09-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport
Nat Commun, 13, 2022
7LDK
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BU of 7ldk by Molmil
Structure of human respiratory syncytial virus nonstructural protein 2 (NS2)
Descriptor: CHLORIDE ION, D(-)-TARTARIC ACID, Non-structural protein 2
Authors:Chatterjee, S, Borek, D, Otwinowski, Z, Amarasinghe, G.K, Leung, D.W.
Deposit date:2021-01-13
Release date:2021-03-17
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2.
Proc.Natl.Acad.Sci.USA, 118, 2021
7T9V
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BU of 7t9v by Molmil
Crystal structure of hSTING with the agonist, SHR171032
Descriptor: (3S,4S)-4-(3-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-benzimidazol-1-yl}propyl)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein
Authors:Chowdhury, R, Miller, M.
Deposit date:2021-12-20
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Sci Rep, 12, 2022
7T9U
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BU of 7t9u by Molmil
Crystal structure of hSTING with an agonist (SHR169224)
Descriptor: (3S,4S)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4-(prop-2-en-1-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein
Authors:Chowdhury, R, Miller, M.
Deposit date:2021-12-20
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Sci Rep, 12, 2022
4YP1
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BU of 4yp1 by Molmil
Misting with CDA
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of interferon genes protein
Authors:Chin, K.H, Chen, C.K, Tu, Z.I, Chou, S.H.
Deposit date:2015-03-12
Release date:2015-10-07
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Insights into the Distinct Binding Mode of Cyclic Di-AMP with SaCpaA_RCK.
Biochemistry, 54, 2015
7MHC
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BU of 7mhc by Molmil
Structure of human STING in complex with MK-1454
Descriptor: (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-bis(sulfanyl)octahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein
Authors:Lesburg, C.A.
Deposit date:2021-04-15
Release date:2022-04-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:A kinase-cGAS cascade to synthesize a therapeutic STING activator.
Nature, 603, 2022
6CFF
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BU of 6cff by Molmil
Stimulator of Interferon Genes Human
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of interferon genes protein
Authors:Fernandez, D, Li, L, Ergun, S.L.
Deposit date:2018-02-14
Release date:2019-03-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Cell, 178, 2019
7X9P
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BU of 7x9p by Molmil
Crystal structure of human STING complexed with compound BSP17
Descriptor: 4-[6-methoxy-5-[3-[[6-methoxy-2-(4-oxidanyl-4-oxidanylidene-butanoyl)-1-benzoselenophen-5-yl]oxy]propoxy]-1-benzoselenophen-2-yl]-4-oxidanylidene-butanoic acid, Stimulator of interferon genes protein
Authors:Pan, L, Guan, X, Feng, X, Li, Z, Bian, J.
Deposit date:2022-03-15
Release date:2023-03-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of Selenium-containing STING agonists as orally available anti tumor agents
To be published
6X5A
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BU of 6x5a by Molmil
The mouse cGAS catalytic domain binding to human nucleosome that purified from HEK293T cells
Descriptor: Cyclic GMP-AMP synthase, DNA (natural), Histone H2A type 1, ...
Authors:Pengbiao, X, Pingwei, L, Baoyu, Z.
Deposit date:2020-05-25
Release date:2020-09-16
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.36 Å)
Cite:The molecular basis of tight nuclear tethering and inactivation of cGAS.
Nature, 587, 2020
7UAJ
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BU of 7uaj by Molmil
Crystal structure of apo HPV16 E6
Descriptor: Maltose/maltodextrin-binding periplasmic protein,Protein E6, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Shen, Q, Leonard, P.G, Cross, J.B.
Deposit date:2022-03-13
Release date:2023-03-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Disorder-to-order transition of the interdomain linker of HPV E6 upon E6AP binding reshapes p53 binding pocket
To Be Published

221051

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