6S27
Crystal structure of human wild type STING in complex with 2'3'-cyclic-GMP-2'F-2'dAMP
Summary for 6S27
Entry DOI | 10.2210/pdb6s27/pdb |
Descriptor | Stimulator of interferon protein, 2'3'-cyclic-GMP-2'F-2'dAMP (3 entities in total) |
Functional Keywords | activator, membrane protein, immune system, receptor, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 23865.47 |
Authors | |
Primary citation | Novotna, B.,Vanekova, L.,Zavrel, M.,Budesinsky, M.,Dejmek, M.,Smola, M.,Gutten, O.,Tehrani, Z.A.,Pimkova Polidarova, M.,Brazdova, A.,Liboska, R.,Stepanek, I.,Vavrina, Z.,Jandusik, T.,Nencka, R.,Rulisek, L.,Boura, E.,Brynda, J.,Pav, O.,Birkus, G. Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations. J.Med.Chem., 62:10676-10690, 2019 Cited by PubMed: 31715099DOI: 10.1021/acs.jmedchem.9b01062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.802 Å) |
Structure validation
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