8T5K

Crystal structure of STING CTD in complex with BDW-OH

Summary for 8T5K

• Entry DOI: 10.2210/pdb8t5k/pdb
• Descriptor: Stimulator of interferon genes protein, {[(4S)-8,9-dimethylthieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3-yl]sulfanyl}acetic acid (3 entities in total)
• Functional Keywords: mediator of irf3 activation, stimulator of interferon genes protein, antiviral protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 21851.58

Authors

Li, Y.,Li, P.,Sun, D. (deposition date: 2023-06-13, release date: 2023-07-12, Last modification date: 2023-10-25)

• Primary citation: Tang, Z.,Zhao, J.,Li, Y.,Tomer, S.,Selvaraju, M.,Tien, N.,Sun, D.,Johnson, D.K.,Zhen, A.,Li, P.,Wang, J.; Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants.; Biorxiv, 2023; PubMed: 37425806; DOI: 10.1101/2023.07.02.547363

Experimental method

X-RAY DIFFRACTION (1.95 Å)