4XR8

Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution

Summary for 4XR8

Entry DOI	10.2210/pdb4xr8/pdb
Related	4GIZ
Related PRD ID	PRD_900001
Descriptor	Maltose-binding periplasmic protein, ubiquitin ligase E6AP, Cellular tumor antigen p53, Protein E6, ... (8 entities in total)
Functional Keywords	human papillomavirus 16, e6 oncoprotein, ubiquitin-ligase e6ap, tumor suppressor p53, p53 degradation, viral protein-antitumor protein, viral protein- antitumor protein complex, viral protein/ antitumor protein
Biological source	Escherichia coli More
Total number of polymer chains	6
Total formula weight	166669.39
Authors	Martinez-Zapien, D.,Ruiz, F.X.,Mitschler, A.,Podjarny, A.,Trave, G.,Zanier, K. (deposition date: 2015-01-20, release date: 2016-02-03, Last modification date: 2024-01-10)
Primary citation	Martinez-Zapien, D.,Ruiz, F.X.,Poirson, J.,Mitschler, A.,Ramirez, J.,Forster, A.,Cousido-Siah, A.,Masson, M.,Pol, S.V.,Podjarny, A.,Trave, G.,Zanier, K. Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature, 529:541-545, 2016 Cited by PubMed: 26789255 DOI: 10.1038/nature16481 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation