7OB3

hSTING in complex with 3',3'-c-di-araAMP

Summary for 7OB3

• Entry DOI: 10.2210/pdb7ob3/pdb
• Descriptor: Stimulator of interferon genes protein, 3',3'-c-di-araAMP (3 entities in total)
• Functional Keywords: cdn, innate immune system, receptor, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 23847.48

Authors

Smola, M.,Boura, E. (deposition date: 2021-04-20, release date: 2022-05-04, Last modification date: 2024-01-31)

• Primary citation: Novotna, B.,Hola, L.,Stas, M.,Gutten, O.,Smola, M.,Zavrel, M.,Vavrina, Z.,Budesinsky, M.,Liboska, R.,Chevrier, F.,Dobias, J.,Boura, E.,Rulisek, L.,Birkus, G.; Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations; Biochemistry, 2021; DOI: 10.1021/acs.biochem.1c00692

Experimental method

X-RAY DIFFRACTION (2.3 Å)