PDB: 2623 resultsInfo pagesStatus searchChemie searchBIRD

---

6N9D	Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/L133P/L151C/G154A) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) Descriptor: CALCIUM ION, Metalloproteinase inhibitor 1, Stromelysin-1, ... Authors: Raeeszadeh-Sarmazdeh, M, Radisky, E.S, Sankaran, B. Deposit date: 2018-12-03 Release date: 2019-05-15 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition. J.Biol.Chem., 294, 2019
8UDZ	The Structure of LTBP-49247 Fab Bound to TGFbeta1 Small Latent Complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, LTBP-49247 Fab Heavy Chain, LTBP-49247 Fab Light Chain, ... Authors: Streich Jr, F.C, Nicholls, S.B, Boston, C.J, Ramachandran, S. Deposit date: 2023-09-29 Release date: 2024-07-17 Method: X-RAY DIFFRACTION (2.21 Å) Cite: An antibody that inhibits TGF-beta 1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis. Sci.Signal., 17, 2024
3V4O	Human MALT1 (caspase domain) in complex with an irreversible peptidic inhibitor Descriptor: MALT1 Inhibitor, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 Authors: Renatus, M, Wiesmann, C. Deposit date: 2011-12-15 Release date: 2012-03-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Determinants of MALT1 Protease Activity. J.Mol.Biol., 419, 2012
9FQ0	Human NatA-NAC-MAP1 80S ribosome complex Descriptor: 28S rRNA, 5.8S rRNA, 60S ribosomal protein L19, ... Authors: Klein, M.A, Wild, K, Sinning, I. Deposit date: 2024-06-14 Release date: 2024-07-03 Last modified: 2024-10-02 Method: ELECTRON MICROSCOPY (4.67 Å) Cite: Multi-protein assemblies orchestrate co-translational enzymatic processing on the human ribosome. Nat Commun, 15, 2024
8VG1	Cryo-EM structure of FoxA1 and GATA4 in complex with ALBN1 nucleosome Descriptor: DNA (171-MER), Hepatocyte nuclear factor 3-alpha, Histone H2A type 1-B/E, ... Authors: Zhou, B.R, Bai, Y. Deposit date: 2023-12-22 Release date: 2024-08-07 Last modified: 2024-09-11 Method: ELECTRON MICROSCOPY (2.48 Å) Cite: Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4. Mol.Cell, 84, 2024
1C5M	STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR Descriptor: PROTEIN (COAGULATION FACTOR X) Authors: Katz, B.A, Mackman, R, Luong, C, Radika, K, Martelli, A, Sprengeler, P.A, Wang, J, Chan, H, Wong, L. Deposit date: 1999-12-22 Release date: 2000-12-22 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem.Biol., 7, 2000
7Y1R	Human L-TGF-beta1 in complex with the anchor protein LRRC33 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Duan, Z, Zhang, Z. Deposit date: 2022-06-08 Release date: 2022-08-31 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (4.01 Å) Cite: Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8. Nat Commun, 13, 2022
8VG0	Cryo-EM structure of GATA4 in complex with ALBN1 nucleosome Descriptor: DNA (159-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... Authors: Zhou, B.R, Bai, Y. Deposit date: 2023-12-22 Release date: 2024-08-07 Last modified: 2024-09-11 Method: ELECTRON MICROSCOPY (3.07 Å) Cite: Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4. Mol.Cell, 84, 2024
7Y1T	Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Duan, Z, Zhang, Z. Deposit date: 2022-06-08 Release date: 2022-08-31 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (3.24 Å) Cite: Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8. Nat Commun, 13, 2022
4U32	Human mesotrypsin complexed with HAI-2 Kunitz domain 1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Kunitz-type protease inhibitor 2, ... Authors: Wang, R, Soares, A.S, Radisky, E.S. Deposit date: 2014-07-18 Release date: 2014-10-15 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN. J.Biol.Chem., 289, 2014
6WXJ	CSF1R signaling is a regulator of pathogenesis in progressive MS Descriptor: 4-(3-{[(2S)-2-(6-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl}-3H-imidazo[4,5-b]pyridin-6-yl)-2-methylbut-3-yn-2-amine, Macrophage colony-stimulating factor 1 receptor Authors: Liu, J. Deposit date: 2020-05-10 Release date: 2021-02-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.62 Å) Cite: CSF1R signaling is a regulator of pathogenesis in progressive MS. Cell Death Dis, 11, 2020
8EVJ	CX3CR1 nucleosome bound PU.1 and C/EBPa Descriptor: DNA (167-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... Authors: Guan, R, Bai, Y, Lian, T. Deposit date: 2022-10-20 Release date: 2023-11-01 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha. Nat.Struct.Mol.Biol., 31, 2024
8EVI	CX3CR1 nucleosome and PU.1 complex containing disulfide bond mutations Descriptor: DNA (167-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... Authors: Lian, T, Guan, R, Bai, Y. Deposit date: 2022-10-20 Release date: 2023-11-01 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (2.64 Å) Cite: Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha. Nat.Struct.Mol.Biol., 31, 2024
8P2K	Ternary complex of translating ribosome, NAC and METAP1 Descriptor: 18s rRNA, 28S rRNA, 40S ribosomal protein S11, ... Authors: Jia, M, Jaskolowski, M, Scaiola, A, Jomaa, A, Ban, N. Deposit date: 2023-05-16 Release date: 2023-07-19 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: NAC controls cotranslational N-terminal methionine excision in eukaryotes. Science, 380, 2023
5FFO	Integrin alpha V beta 6 in complex with pro-TGF-beta Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Dong, X, Zhao, B, Springer, T.A. Deposit date: 2015-12-18 Release date: 2017-01-25 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3.49 Å) Cite: Force interacts with macromolecular structure in activation of TGF-beta. Nature, 542, 2017
6UJA	Integrin alpha-v beta-8 in complex with pro-TGF-beta1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. Deposit date: 2019-10-02 Release date: 2020-02-05 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180, 2020
8VFY	Cryo-EM structure of FoxA1 in complex with ALBN1 nucleosome (class 1) Descriptor: DNA (171-MER), Hepatocyte nuclear factor 3-alpha, Histone H2A type 1-B/E, ... Authors: Zhou, B.R, Bai, Y. Deposit date: 2023-12-22 Release date: 2024-08-07 Last modified: 2024-09-11 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4. Mol.Cell, 84, 2024
8VFZ	Cryo-EM structure of FoxA1 in complex with ALBN1 nucleosome (class 2) Descriptor: DNA (171-MER), Hepatocyte nuclear factor 3-alpha, Histone H2A type 1-B/E, ... Authors: Zhou, B.R, Bai, Y. Deposit date: 2023-12-22 Release date: 2024-08-07 Last modified: 2024-09-11 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4. Mol.Cell, 84, 2024
3KZ1	Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho guanine nucleotide exchange factor 11, ... Authors: Chen, Z, Sternweis, P.C, Sprang, S.R. Deposit date: 2009-12-07 Release date: 2010-04-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. J.Biol.Chem., 285, 2010
8CGC	Structure of CSF1R in complex with a pyrollopyrimidine (compound 23) Descriptor: (2S)-2-hydroxybutanedioic acid, GLYCEROL, Macrophage colony-stimulating factor 1 receptor, ... Authors: Aarhus, T.I, Bjornstad, F, Wolowczyk, C, Larsen, K.U, Rognstad, L, Leithaug, T, Unger, A, Habenberger, P, Wolff, A, Bjorkoy, G, Pridans, C, Eickhoff, J, Klebl, B, Hoff, B.H, Sundby, E. Deposit date: 2023-02-03 Release date: 2023-05-24 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.925 Å) Cite: Synthesis and Development of Highly Selective Pyrrolo[2,3- d ]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form. J.Med.Chem., 66, 2023
5DMR	Crystal Structure of C-terminal domain of mouse eRF1 in complex with RNase H domain of RT of Moloney Murine Leukemia Virus Descriptor: Eukaryotic peptide chain release factor subunit 1, Reverse transcriptase/ribonuclease H p80 Authors: Tang, X, Song, H. Deposit date: 2015-09-09 Release date: 2016-07-06 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus Nat Commun, 7, 2016
6E5G	Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Descriptor: 1-(2-{[3-(trifluoromethyl)phenyl]amino}phenyl)ethan-1-one, Transcriptional enhancer factor TEF-4 Authors: Bum-Erdene, K, Gonzalez-Gutierrez, G, Meroueh, S.O. Deposit date: 2018-07-20 Release date: 2019-01-09 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.43 Å) Cite: Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction. Cell Chem Biol, 26, 2019
8CA5	Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 3). Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... Authors: Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J. Deposit date: 2023-01-24 Release date: 2023-12-20 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. Embo J., 43, 2024
6XM2	The structure of the 4A11.v7 antibody in complex with human TGFb2 Descriptor: 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized, 4A11.v7 kappa light chain Fab (VL-CL) humanized, Transforming growth factor beta-2 Authors: Lupardus, P.J, Yin, J.P. Deposit date: 2020-06-29 Release date: 2021-07-07 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.91 Å) Cite: TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis. Sci Transl Med, 13, 2021
1RZ4	Crystal Structure of Human eIF3k Descriptor: Eukaryotic translation initiation factor 3 subunit 11, SULFATE ION Authors: Wei, Z, Zhang, P, Zhou, Z, Gong, W. Deposit date: 2003-12-23 Release date: 2004-09-21 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of human eIF3k, the first structure of eIF3 subunits J.Biol.Chem., 279, 2004

<10111213141516171819202122232425>