8E0G
| Re-refined model of active mu-opioid receptor (PDB 5c1m) as an adduct with BU72 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol, CHOLESTEROL, ... | Authors: | Munro, T.A. | Deposit date: | 2022-08-09 | Release date: | 2023-10-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Reanalysis of a mu opioid receptor crystal structure reveals a covalent adduct with BU72. Bmc Biol., 21, 2023
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8DZR
| GR89,696 bound Kappa Opioid Receptor in complex with gustducin | Descriptor: | G alpha gustducin protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Fay, J.F, Che, T. | Deposit date: | 2022-08-08 | Release date: | 2023-05-03 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8DZS
| GR89,696 bound Kappa Opioid Receptor in complex with Gz | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(z) subunit alpha, ... | Authors: | Fay, J.F, Che, T. | Deposit date: | 2022-08-08 | Release date: | 2023-05-03 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8DZP
| momSalB bound Kappa Opioid Receptor in complex with Gi1 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Fay, J.F, Che, T. | Deposit date: | 2022-08-08 | Release date: | 2023-05-03 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8DZQ
| momSalB bound Kappa Opioid Receptor in complex with GoA | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | Authors: | Fay, J.F, Che, T. | Deposit date: | 2022-08-08 | Release date: | 2023-05-03 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8DWC
| CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22 | Descriptor: | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Y, Cao, C, Fay, J.F, Roth, B.L. | Deposit date: | 2022-08-01 | Release date: | 2022-11-02 | Last modified: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nat.Chem.Biol., 19, 2023
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8DWH
| CryoEM structure of Gq-coupled MRGPRX1 with ligand Compound-16 | Descriptor: | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Y, Cao, C, Fay, J.F, Roth, B.L. | Deposit date: | 2022-08-01 | Release date: | 2022-11-02 | Last modified: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nat.Chem.Biol., 19, 2023
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8DWG
| CryoEM structure of Gq-coupled MRGPRX1 with peptide ligand BAM8-22 and positive allosteric modulator ML382 | Descriptor: | 2-[(cyclopropanesulfonyl)amino]-N-(2-ethoxyphenyl)benzamide, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Liu, Y, Cao, C, Fay, J.F, Roth, B.L. | Deposit date: | 2022-08-01 | Release date: | 2022-11-02 | Last modified: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nat.Chem.Biol., 19, 2023
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7YOO
| Complex structure of Neuropeptide Y Y2 receptor in complex with NPY and Gi | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Kang, H, Park, C, Kim, J, Choi, H.-J. | Deposit date: | 2022-08-01 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling. Structure, 31, 2023
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7YON
| Complex structure of Neuropeptide Y Y2 receptor in complex with PYY(3-36) and Gi | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Kang, H, Park, C, Kim, J, Choi, H.-J. | Deposit date: | 2022-08-01 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling. Structure, 31, 2023
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7YMH
| Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to noradrenaline | Descriptor: | Nb29, Noradrenaline, alpha1A-adrenergic receptor, ... | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | Deposit date: | 2022-07-28 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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7YMJ
| Cryo-EM structure of alpha1AAR-Nb6 complex bound to tamsulosin | Descriptor: | Nb6, Tamsulosin, alpha1A-adrenergic receptor | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | Deposit date: | 2022-07-28 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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7YM8
| Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline | Descriptor: | CHOLESTEROL HEMISUCCINATE, Oxymetazoline, alpha1A adrenergic receptor, ... | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | Deposit date: | 2022-07-27 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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8DU3
| Crystal structure of A2AAR-StaR2-bRIL in complex with compound 21a | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (4M)-6-bromo-4-(furan-2-yl)quinazolin-2-amine, Adenosine receptor A2a, ... | Authors: | Shiriaeva, A, Stauch, B, Han, G.W, Cherezov, V. | Deposit date: | 2022-07-26 | Release date: | 2022-08-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | High ligand efficiency quinazoline compounds as novel A 2A adenosine receptor antagonists. Eur.J.Med.Chem., 241, 2022
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7YKD
| Cryo-EM structure of the human chemerin receptor 1 complex with the C-terminal nonapeptide of chemerin | Descriptor: | CHOLESTEROL, Chemerin-like receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Chen, G, Liao, Q, Ye, R.D, Wang, J. | Deposit date: | 2022-07-22 | Release date: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin. Proc.Natl.Acad.Sci.USA, 120, 2023
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7YK6
| Cryo-EM structure of the compound 4-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex | Descriptor: | 1-[2-(4-chlorophenyl)ethyl]-3-[(7-ethyl-5-oxidanyl-1H-indol-3-yl)methylideneamino]guanidine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Chen, Y, Zhou, Q.T, Wang, J, Xu, Y.W, Wang, Y, Yan, J.H, Wang, Y.B, Zhu, Q, Zhao, F.H, Li, C.H, Chen, C.W, Cai, X.Q, Bathgate, R.A.D, Shen, C, Liu, H, Xu, H.E, Yang, D.H, Wang, M.W. | Deposit date: | 2022-07-21 | Release date: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4). Nat Commun, 14, 2023
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7YK7
| Cryo-EM structure of the DC591053-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... | Authors: | Chen, Y, Zhou, Q.T, Wang, J, Xu, Y.W, Wang, Y, Yan, J.H, Wang, Y.B, Zhu, Q, Zhao, F.H, Li, C.H, Chen, C.W, Cai, X.Q, Bathgate, R.A.D, Shen, C, Xu, H.E, Yang, D.H, Liu, H, Wang, M.W. | Deposit date: | 2022-07-21 | Release date: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4). Nat Commun, 14, 2023
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7YJ4
| Cryo-EM structure of the INSL5-bound human relaxin family peptidereceptor 4 (RXFP4)-Gi complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... | Authors: | Chen, Y, Zhou, Q.T, Wang, J, Xu, Y.W, Wang, Y, Yan, J.H, Wang, Y.B, Zhu, Q, Zhao, F.H, Li, C.H, Chen, C.W, Cai, X.Q, Bathgate, R.A.D, Shen, C, Liu, H, Xu, H.E, Yang, D.H, Wang, M.W. | Deposit date: | 2022-07-19 | Release date: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4). Nat Commun, 14, 2023
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7YIT
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8DPH
| Cryo-EM structure of the 5HT2C receptor (VGV isoform) bound to lorcaserin | Descriptor: | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2022-07-15 | Release date: | 2022-08-24 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors. Cell Rep, 40, 2022
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8DPF
| Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to lorcaserin | Descriptor: | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2022-07-15 | Release date: | 2022-08-24 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors. Cell Rep, 40, 2022
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8DPI
| Cryo-EM structure of the 5HT2C receptor (VSV isoform) bound to lorcaserin | Descriptor: | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2022-07-15 | Release date: | 2022-08-24 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors. Cell Rep, 40, 2022
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8DPG
| Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to psilocin | Descriptor: | 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2022-07-15 | Release date: | 2022-08-24 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors. Cell Rep, 40, 2022
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7YFC
| Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex | Descriptor: | CHOLESTEROL, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Im, D, Iwata, S, Asada, H. | Deposit date: | 2022-07-08 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into the agonists binding and receptor selectivity of human histamine H 4 receptor. Nat Commun, 14, 2023
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7YFD
| Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex | Descriptor: | 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate, CHOLESTEROL, Engineered G-alpha-q, ... | Authors: | Im, D, Iwata, S, Asada, H. | Deposit date: | 2022-07-08 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into the agonists binding and receptor selectivity of human histamine H 4 receptor. Nat Commun, 14, 2023
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