8DU3

Crystal structure of A2AAR-StaR2-bRIL in complex with compound 21a

Summary for 8DU3

Entry DOI	10.2210/pdb8du3/pdb
Descriptor	Adenosine receptor A2a, soluble cytochrome b562 chimera,Soluble cytochrome b562,Adenosine receptor A2a, (4M)-6-bromo-4-(furan-2-yl)quinazolin-2-amine, CHOLESTEROL, ... (6 entities in total)
Functional Keywords	gpcr, lcp, antagonists, alzheimer, parkinson, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	57348.96
Authors	Shiriaeva, A.,Stauch, B.,Han, G.W.,Cherezov, V. (deposition date: 2022-07-26, release date: 2022-08-10, Last modification date: 2023-10-18)
Primary citation	Bolteau, R.,Duroux, R.,Laversin, A.,Vreulz, B.,Shiriaeva, A.,Stauch, B.,Han, G.W.,Cherezov, V.,Renault, N.,Barczyk, A.,Ravez, S.,Coevoet, M.,Melnyk, P.,Liberelle, M.,Yous, S. High ligand efficiency quinazoline compounds as novel A 2A adenosine receptor antagonists. Eur.J.Med.Chem., 241:114620-114620, 2022 Cited by PubMed: 35933788 DOI: 10.1016/j.ejmech.2022.114620 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation