7YJ4

Cryo-EM structure of the INSL5-bound human relaxin family peptidereceptor 4 (RXFP4)-Gi complex

Summary for 7YJ4

• Entry DOI: 10.2210/pdb7yj4/pdb
• EMDB information: 33871
• Descriptor: Insulin-like peptide INSL5 A chain, Insulin-like peptide INSL5 B chain, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: human relaxin family peptide receptor 4, g protein-coupled receptor, ligand recognition, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 158937.16

Authors

Chen, Y.,Zhou, Q.T.,Wang, J.,Xu, Y.W.,Wang, Y.,Yan, J.H.,Wang, Y.B.,Zhu, Q.,Zhao, F.H.,Li, C.H.,Chen, C.W.,Cai, X.Q.,Bathgate, R.A.D.,Shen, C.,Liu, H.,Xu, H.E.,Yang, D.H.,Wang, M.W. (deposition date: 2022-07-19, release date: 2023-03-01)

• Primary citation: Chen, Y.,Zhou, Q.,Wang, J.,Xu, Y.,Wang, Y.,Yan, J.,Wang, Y.,Zhu, Q.,Zhao, F.,Li, C.,Chen, C.W.,Cai, X.,Bathgate, R.A.D.,Shen, C.,Eric Xu, H.,Yang, D.,Liu, H.,Wang, M.W.; Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4).; Nat Commun, 14:492-492, 2023; PubMed: 36717591; DOI: 10.1038/s41467-023-36182-z

Experimental method

ELECTRON MICROSCOPY (3.19 Å)