8ESC
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![BU of 8esc by Molmil](/molmil-images/mine/8esc) | Structure of the Yeast NuA4 Histone Acetyltransferase Complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin-related protein 4, ... | Authors: | Patel, A.B, Zukin, S.A, Nogales, E. | Deposit date: | 2022-10-13 | Release date: | 2022-11-16 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure and flexibility of the yeast NuA4 histone acetyltransferase complex. Elife, 11, 2022
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8BAV
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![BU of 8bav by Molmil](/molmil-images/mine/8bav) | Secretagogin (human) in complex with its target peptide from SNAP-25 | Descriptor: | ACETATE ION, CALCIUM ION, Green fluorescent protein,Synaptosomal-associated protein 25, ... | Authors: | Schnell, R, Szodorai, E. | Deposit date: | 2022-10-12 | Release date: | 2024-04-03 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues. Proc.Natl.Acad.Sci.USA, 121, 2024
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8H59
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![BU of 8h59 by Molmil](/molmil-images/mine/8h59) | A fungal MAP kinase in complex with an inhibitor | Descriptor: | Mitogen-activated protein kinase MPS1, ~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]-8-[2-methoxy-5-(trifluoromethyloxy)phenyl]-1,6-naphthyridine-2-carboxamide | Authors: | Kong, Z, Zhang, X, Wang, D, Liu, J. | Deposit date: | 2022-10-12 | Release date: | 2023-02-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi. Mbio, 14, 2023
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8ERN
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![BU of 8ern by Molmil](/molmil-images/mine/8ern) | Cyclin-free CDK2 in complex with Cpd21 | Descriptor: | Cyclin-dependent kinase 2, GLYCEROL, N,3-dimethyl-4-({7-[(2S)-2-methylpyrrolidine-1-carbonyl]quinazolin-2-yl}amino)benzene-1-sulfonamide | Authors: | Murray, J.M, Oh, A. | Deposit date: | 2022-10-12 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Cyclin-free CDK2 in complex with Cpd21 To Be Published
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8H55
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![BU of 8h55 by Molmil](/molmil-images/mine/8h55) | The structure of zebrafish angiotensinogen | Descriptor: | Angiotensinogen, SULFATE ION | Authors: | Zhou, A, Wei, H. | Deposit date: | 2022-10-12 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | BIOLOGICAL IMPLICATIONS OF A 2 ANGSTROMS STRUCTURE OF DIMERIC ANGIOTENSINOGEN To Be Published
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8ERD
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![BU of 8erd by Molmil](/molmil-images/mine/8erd) | Cyclin-free CDK2 in complex with Cpd17 | Descriptor: | (2-{[1-(methanesulfonyl)piperidin-4-yl]amino}quinazolin-7-yl)[(2S)-2-methylpyrrolidin-1-yl]methanone, Cyclin-dependent kinase 2 | Authors: | Murray, J.M, Oh, A. | Deposit date: | 2022-10-11 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Cyclin-free CDK2 in complex with Cpd17 To Be Published
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8H4V
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![BU of 8h4v by Molmil](/molmil-images/mine/8h4v) | Mincle CRD complex with PGL trisaccharide | Descriptor: | (2~{R},3~{R},4~{S},5~{S},6~{R})-6-(methoxymethyl)oxane-2,3,4,5-tetrol-(1-4)-6-deoxy-2,3-di-O-methyl-alpha-L-mannopyranose-(1-2)-3-O-methyl-alpha-L-rhamnopyranose, C-type lectin domain family 4 member E, CALCIUM ION | Authors: | Ishizuka, S, Nagae, M, Yamasaki, S. | Deposit date: | 2022-10-11 | Release date: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand. Acs Cent.Sci., 9, 2023
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8H4R
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![BU of 8h4r by Molmil](/molmil-images/mine/8h4r) | The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, G1/S-specific cyclin-E1, ... | Authors: | Gui, W, Wang, F, Cheng, W, Gao, J, Huang, Y, Ouyang, Z. | Deposit date: | 2022-10-11 | Release date: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus To Be Published
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8H4X
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![BU of 8h4x by Molmil](/molmil-images/mine/8h4x) | Structure of cleaved Serpin B9 | Descriptor: | 1,2-ETHANEDIOL, Serpin B9, ZINC ION | Authors: | Zhou, A, Yan, T. | Deposit date: | 2022-10-11 | Release date: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Expression, purification and crystallization of cleaved Serpin B9 To Be Published
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8H4I
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![BU of 8h4i by Molmil](/molmil-images/mine/8h4i) | DHA-bound FFAR4 in complex with Gs | Descriptor: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Yin, H. | Deposit date: | 2022-10-10 | Release date: | 2023-06-21 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8H4L
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![BU of 8h4l by Molmil](/molmil-images/mine/8h4l) | DHA-bound FFAR4 in complex with Gq | Descriptor: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Yin, H. | Deposit date: | 2022-10-10 | Release date: | 2023-06-21 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8H4K
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![BU of 8h4k by Molmil](/molmil-images/mine/8h4k) | GW9508-bound FFAR4 in complex with Gq | Descriptor: | 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Yin, H. | Deposit date: | 2022-10-10 | Release date: | 2023-06-21 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8H3U
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![BU of 8h3u by Molmil](/molmil-images/mine/8h3u) | Inhibitor-bound EP, polyA model | Descriptor: | Enteropeptidase catalytic light chain, Enteropeptidase non-catalytic heavy chain | Authors: | Ding, Z.Y, Huang, H.J. | Deposit date: | 2022-10-09 | Release date: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase. Nat Commun, 13, 2022
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8H3S
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![BU of 8h3s by Molmil](/molmil-images/mine/8h3s) | Substrate-bound EP, polyA model | Descriptor: | Enteropeptidase catalytic light chain, Enteropeptidase non-catalytic heavy chain, Serine protease 1 | Authors: | Ding, Z.Y, Huang, H.J. | Deposit date: | 2022-10-09 | Release date: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase. Nat Commun, 13, 2022
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8H3W
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![BU of 8h3w by Molmil](/molmil-images/mine/8h3w) | |
8H3V
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![BU of 8h3v by Molmil](/molmil-images/mine/8h3v) | Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC | Descriptor: | DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. | Deposit date: | 2022-10-09 | Release date: | 2023-10-04 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
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8H40
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![BU of 8h40 by Molmil](/molmil-images/mine/8h40) | Cryo-EM structure of the transcription activation complex NtcA-TAC | Descriptor: | DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. | Deposit date: | 2022-10-09 | Release date: | 2023-10-04 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
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8H3H
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![BU of 8h3h by Molmil](/molmil-images/mine/8h3h) | Human ATAD2 Walker B mutant, ATP state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family AAA domain-containing protein 2 | Authors: | Cho, C, Song, J. | Deposit date: | 2022-10-08 | Release date: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication. Commun Biol, 6, 2023
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8H36
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![BU of 8h36 by Molmil](/molmil-images/mine/8h36) | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a dimeric complex | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | Deposit date: | 2022-10-08 | Release date: | 2023-10-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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8H37
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![BU of 8h37 by Molmil](/molmil-images/mine/8h37) | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a tetrameric complex | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | Deposit date: | 2022-10-08 | Release date: | 2023-10-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (7.52 Å) | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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8EQ5
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![BU of 8eq5 by Molmil](/molmil-images/mine/8eq5) | Crystal structure of the N-terminal kinase domain of RSK2 in complex with SPRED2 (131-160) | Descriptor: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, Ribosomal protein S6 kinase alpha-3, Sprouty-related, ... | Authors: | Bonsor, D.A, Lopez, J, McCormick, F, Simanshu, D.K. | Deposit date: | 2022-10-07 | Release date: | 2023-04-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling. J.Biol.Chem., 299, 2023
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8EQ9
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![BU of 8eq9 by Molmil](/molmil-images/mine/8eq9) | Co-crystal structure of PERK with compound 11 | Descriptor: | (2R)-N-[(4M)-4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-(3-fluorophenyl)-2-hydroxyacetamide, Eukaryotic translation initiation factor 2-alpha kinase 3 | Authors: | Zhu, G, Surman, M.D, Mulvihill, M.J. | Deposit date: | 2022-10-07 | Release date: | 2022-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors. Pharmaceutics, 14, 2022
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8EQD
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![BU of 8eqd by Molmil](/molmil-images/mine/8eqd) | Co-crystal structure of PERK with compound 24 | Descriptor: | (2R)-N-[(4M)-4-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-(3-fluorophenyl)-2-hydroxyacetamide, Eukaryotic translation initiation factor 2-alpha kinase 3 | Authors: | Zhu, G, Surman, M.D, Mulvihill, M.J. | Deposit date: | 2022-10-07 | Release date: | 2022-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors. Pharmaceutics, 14, 2022
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8EQE
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![BU of 8eqe by Molmil](/molmil-images/mine/8eqe) | Co-crystal structure of PERK with compound 26 | Descriptor: | (2R)-N-[(4M)-4-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetamide, Eukaryotic translation initiation factor 2-alpha kinase 3 | Authors: | Zhu, G, Surman, M.D, Mulvihill, M.J. | Deposit date: | 2022-10-07 | Release date: | 2022-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.559 Å) | Cite: | Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors. Pharmaceutics, 14, 2022
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8EPL
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![BU of 8epl by Molmil](/molmil-images/mine/8epl) | Human R-type voltage-gated calcium channel Cav2.3 at 3.1 Angstrom resolution | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gao, S, Yao, X, Yan, N. | Deposit date: | 2022-10-06 | Release date: | 2022-12-14 | Last modified: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structures of the R-type human Ca v 2.3 channel reveal conformational crosstalk of the intracellular segments. Nat Commun, 13, 2022
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