8EQD

Co-crystal structure of PERK with compound 24

This is a non-PDB format compatible entry.

Summary for 8EQD

• Entry DOI: 10.2210/pdb8eqd/pdb
• Related: 8EQ9
• Descriptor: Eukaryotic translation initiation factor 2-alpha kinase 3, (2R)-N-[(4M)-4-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-(3-fluorophenyl)-2-hydroxyacetamide (2 entities in total)
• Functional Keywords: kinase, perk, inhibitor, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 37235.81

Authors

Zhu, G.,Surman, M.D.,Mulvihill, M.J. (deposition date: 2022-10-07, release date: 2022-11-30, Last modification date: 2023-10-25)

• Primary citation: Stokes, M.E.,Surman, M.D.,Calvo, V.,Surguladze, D.,Li, A.H.,Gasparek, J.,Betzenhauser, M.,Zhu, G.,Du, H.,Rigby, A.C.,Mulvihill, M.J.; Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors.; Pharmaceutics, 14:-, 2022; PubMed: 36297668; DOI: 10.3390/pharmaceutics14102233

Experimental method

X-RAY DIFFRACTION (2.92 Å)