8H36

Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a dimeric complex

Summary for 8H36

• Entry DOI: 10.2210/pdb8h36/pdb
• EMDB information: 34452
• Descriptor: E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... (5 entities in total)
• Functional Keywords: ligase, complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 513382.38

Authors

Hu, Y.,Mao, Q.,Chen, Z.,Sun, L. (deposition date: 2022-10-08, release date: 2023-10-11, Last modification date: 2024-03-20)

• Primary citation: Hu, Y.,Zhang, Z.,Mao, Q.,Zhang, X.,Hao, A.,Xun, Y.,Wang, Y.,Han, L.,Zhan, W.,Liu, Q.,Yin, Y.,Peng, C.,Moresco, E.M.Y.,Chen, Z.,Beutler, B.,Sun, L.; Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.; Nat.Struct.Mol.Biol., 31:336-350, 2024; PubMed: 38332366; DOI: 10.1038/s41594-023-01182-6

Experimental method

ELECTRON MICROSCOPY (4.6 Å)