8H36
Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a dimeric complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, H (E, D) | E3 ubiquitin-protein ligase RBX1 | polymer | 108 | 12290.0 | 2 | UniProt (P62877) Pfam (PF12678) | Homo sapiens (human) | E3 ubiquitin-protein transferase RBX1,Protein ZYP,RING finger protein 75,RING-box protein 1,Rbx1,Regulator of cullins 1,ROC1 |
| 2 | B, E (A, B) | Kelch repeat and BTB domain-containing protein 2 | polymer | 623 | 71431.4 | 2 | UniProt (Q8IY47) Pfam (PF00651) Pfam (PF07707) Pfam (PF01344) | Homo sapiens (human) | BTB and kelch domain-containing protein 1 |
| 3 | C, F (G, H) | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 724 | 83710.3 | 2 | UniProt (P27986) Pfam (PF00017) Pfam (PF00620) Pfam (PF16454) | Homo sapiens (human) | PI3-kinase regulatory subunit alpha,PI3K regulatory subunit alpha,PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PI3-kinase subunit p85-alpha,PtdIns-3-kinase regulatory subunit p85-alpha |
| 4 | D, G (C, F) | Cullin-3 | polymer | 768 | 89063.3 | 2 | UniProt (Q13618) Pfam (PF00888) Pfam (PF10557) | Homo sapiens (human) | CUL-3 |
| 5 | I, J, K, L, M... (E, D) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) |
Sequence modifications
A, B: 1 - 623 (UniProt: Q8IY47)
| PDB | External Database | Details |
|---|---|---|
| Asp 252 | Ser 252 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 512989.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 392.5 | |
| All* | Total formula weight | 513382.4 |
