8H36

Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a dimeric complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000209	biological_process	protein polyubiquitination
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0070936	biological_process	protein K48-linked ubiquitination
A	1900076	biological_process	regulation of cellular response to insulin stimulus
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	0000209	biological_process	protein polyubiquitination
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0016567	biological_process	protein ubiquitination
B	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0070936	biological_process	protein K48-linked ubiquitination
B	1900076	biological_process	regulation of cellular response to insulin stimulus
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0000209	biological_process	protein polyubiquitination
C	0000278	biological_process	mitotic cell cycle
C	0000922	cellular_component	spindle pole
C	0001822	biological_process	kidney development
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005112	molecular_function	Notch binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005827	cellular_component	polar microtubule
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006513	biological_process	protein monoubiquitination
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006915	biological_process	apoptotic process
C	0006950	biological_process	response to stress
C	0006954	biological_process	inflammatory response
C	0007080	biological_process	mitotic metaphase chromosome alignment
C	0007165	biological_process	signal transduction
C	0007229	biological_process	integrin-mediated signaling pathway
C	0008284	biological_process	positive regulation of cell population proliferation
C	0010467	biological_process	gene expression
C	0010468	biological_process	regulation of gene expression
C	0016020	cellular_component	membrane
C	0016192	biological_process	vesicle-mediated transport
C	0016477	biological_process	cell migration
C	0016567	biological_process	protein ubiquitination
C	0017145	biological_process	stem cell division
C	0030030	biological_process	cell projection organization
C	0030163	biological_process	protein catabolic process
C	0030332	molecular_function	cyclin binding
C	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
C	0031208	molecular_function	POZ domain binding
C	0031398	biological_process	positive regulation of protein ubiquitination
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0031514	cellular_component	motile cilium
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031648	biological_process	protein destabilization
C	0032467	biological_process	positive regulation of cytokinesis
C	0032480	biological_process	negative regulation of type I interferon production
C	0034599	biological_process	cellular response to oxidative stress
C	0035024	biological_process	negative regulation of Rho protein signal transduction
C	0036126	cellular_component	sperm flagellum
C	0040016	biological_process	embryonic cleavage
C	0042802	molecular_function	identical protein binding
C	0043149	biological_process	stress fiber assembly
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
C	0048208	biological_process	COPII vesicle coating
C	0051301	biological_process	cell division
C	0051865	biological_process	protein autoubiquitination
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0070062	cellular_component	extracellular exosome
C	0070936	biological_process	protein K48-linked ubiquitination
C	0071230	biological_process	cellular response to amino acid stimulus
C	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
C	0072686	cellular_component	mitotic spindle
C	0080090	biological_process	regulation of primary metabolic process
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0140252	biological_process	regulation protein catabolic process at postsynapse
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	1900076	biological_process	regulation of cellular response to insulin stimulus
C	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000109	cellular_component	nucleotide-excision repair complex
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000165	biological_process	MAPK cascade
D	0000209	biological_process	protein polyubiquitination
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006283	biological_process	transcription-coupled nucleotide-excision repair
D	0006289	biological_process	nucleotide-excision repair
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006974	biological_process	DNA damage response
D	0007283	biological_process	spermatogenesis
D	0007346	biological_process	regulation of mitotic cell cycle
D	0008270	molecular_function	zinc ion binding
D	0008283	biological_process	cell population proliferation
D	0010506	biological_process	regulation of autophagy
D	0010564	biological_process	regulation of cell cycle process
D	0010824	biological_process	regulation of centrosome duplication
D	0014033	biological_process	neural crest cell differentiation
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019788	molecular_function	NEDD8 transferase activity
D	0030174	biological_process	regulation of DNA-templated DNA replication initiation
D	0030510	biological_process	regulation of BMP signaling pathway
D	0030891	cellular_component	VCB complex
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031297	biological_process	replication fork processing
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032006	biological_process	regulation of TOR signaling
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032480	biological_process	negative regulation of type I interferon production
D	0032814	biological_process	regulation of natural killer cell activation
D	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
D	0034599	biological_process	cellular response to oxidative stress
D	0034644	biological_process	cellular response to UV
D	0040029	biological_process	epigenetic regulation of gene expression
D	0042110	biological_process	T cell activation
D	0042127	biological_process	regulation of cell population proliferation
D	0042752	biological_process	regulation of circadian rhythm
D	0042770	biological_process	signal transduction in response to DNA damage
D	0042981	biological_process	regulation of apoptotic process
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043687	biological_process	post-translational protein modification
D	0044314	biological_process	protein K27-linked ubiquitination
D	0044877	molecular_function	protein-containing complex binding
D	0045116	biological_process	protein neddylation
D	0045732	biological_process	positive regulation of protein catabolic process
D	0045995	biological_process	regulation of embryonic development
D	0046627	biological_process	negative regulation of insulin receptor signaling pathway
D	0046872	molecular_function	metal ion binding
D	0050727	biological_process	regulation of inflammatory response
D	0051298	biological_process	centrosome duplication
D	0051726	biological_process	regulation of cell cycle
D	0060090	molecular_function	molecular adaptor activity
D	0060173	biological_process	limb development
D	0060271	biological_process	cilium assembly
D	0060964	biological_process	regulation of miRNA-mediated gene silencing
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061663	molecular_function	NEDD8 ligase activity
D	0062197	biological_process	cellular response to chemical stress
D	0070936	biological_process	protein K48-linked ubiquitination
D	0071230	biological_process	cellular response to amino acid stimulus
D	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
D	0080135	biological_process	regulation of cellular response to stress
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090734	cellular_component	site of DNA damage
D	0097602	molecular_function	cullin family protein binding
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	0160276	biological_process	negative regulation of beige fat cell differentiation
D	1900076	biological_process	regulation of cellular response to insulin stimulus
D	1901524	biological_process	regulation of mitophagy
D	1901525	biological_process	negative regulation of mitophagy
D	1901987	biological_process	regulation of cell cycle phase transition
D	1902412	biological_process	regulation of mitotic cytokinesis
D	1902499	biological_process	positive regulation of protein autoubiquitination
D	1902883	biological_process	negative regulation of response to oxidative stress
D	1904178	biological_process	negative regulation of adipose tissue development
D	1904263	biological_process	positive regulation of TORC1 signaling
D	1904415	biological_process	regulation of xenophagy
D	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
D	2000001	biological_process	regulation of DNA damage checkpoint
D	2000036	biological_process	regulation of stem cell population maintenance
D	2000104	biological_process	negative regulation of DNA-templated DNA replication
E	0000082	biological_process	G1/S transition of mitotic cell cycle
E	0000109	cellular_component	nucleotide-excision repair complex
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000165	biological_process	MAPK cascade
E	0000209	biological_process	protein polyubiquitination
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005794	cellular_component	Golgi apparatus
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006283	biological_process	transcription-coupled nucleotide-excision repair
E	0006289	biological_process	nucleotide-excision repair
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006513	biological_process	protein monoubiquitination
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006974	biological_process	DNA damage response
E	0007283	biological_process	spermatogenesis
E	0007346	biological_process	regulation of mitotic cell cycle
E	0008270	molecular_function	zinc ion binding
E	0008283	biological_process	cell population proliferation
E	0010506	biological_process	regulation of autophagy
E	0010564	biological_process	regulation of cell cycle process
E	0010824	biological_process	regulation of centrosome duplication
E	0014033	biological_process	neural crest cell differentiation
E	0016567	biological_process	protein ubiquitination
E	0016740	molecular_function	transferase activity
E	0019005	cellular_component	SCF ubiquitin ligase complex
E	0019788	molecular_function	NEDD8 transferase activity
E	0030174	biological_process	regulation of DNA-templated DNA replication initiation
E	0030510	biological_process	regulation of BMP signaling pathway
E	0030891	cellular_component	VCB complex
E	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E	0031297	biological_process	replication fork processing
E	0031461	cellular_component	cullin-RING ubiquitin ligase complex
E	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
E	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
E	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
E	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032006	biological_process	regulation of TOR signaling
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032480	biological_process	negative regulation of type I interferon production
E	0032814	biological_process	regulation of natural killer cell activation
E	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
E	0034599	biological_process	cellular response to oxidative stress
E	0034644	biological_process	cellular response to UV
E	0040029	biological_process	epigenetic regulation of gene expression
E	0042110	biological_process	T cell activation
E	0042127	biological_process	regulation of cell population proliferation
E	0042752	biological_process	regulation of circadian rhythm
E	0042770	biological_process	signal transduction in response to DNA damage
E	0042981	biological_process	regulation of apoptotic process
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043687	biological_process	post-translational protein modification
E	0044314	biological_process	protein K27-linked ubiquitination
E	0044877	molecular_function	protein-containing complex binding
E	0045116	biological_process	protein neddylation
E	0045732	biological_process	positive regulation of protein catabolic process
E	0045995	biological_process	regulation of embryonic development
E	0046627	biological_process	negative regulation of insulin receptor signaling pathway
E	0046872	molecular_function	metal ion binding
E	0050727	biological_process	regulation of inflammatory response
E	0051298	biological_process	centrosome duplication
E	0051726	biological_process	regulation of cell cycle
E	0060090	molecular_function	molecular adaptor activity
E	0060173	biological_process	limb development
E	0060271	biological_process	cilium assembly
E	0060964	biological_process	regulation of miRNA-mediated gene silencing
E	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0061663	molecular_function	NEDD8 ligase activity
E	0062197	biological_process	cellular response to chemical stress
E	0070936	biological_process	protein K48-linked ubiquitination
E	0071230	biological_process	cellular response to amino acid stimulus
E	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
E	0080135	biological_process	regulation of cellular response to stress
E	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
E	0090734	cellular_component	site of DNA damage
E	0097602	molecular_function	cullin family protein binding
E	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
E	0160240	biological_process	RNA polymerase II transcription initiation surveillance
E	0160276	biological_process	negative regulation of beige fat cell differentiation
E	1900076	biological_process	regulation of cellular response to insulin stimulus
E	1901524	biological_process	regulation of mitophagy
E	1901525	biological_process	negative regulation of mitophagy
E	1901987	biological_process	regulation of cell cycle phase transition
E	1902412	biological_process	regulation of mitotic cytokinesis
E	1902499	biological_process	positive regulation of protein autoubiquitination
E	1902883	biological_process	negative regulation of response to oxidative stress
E	1904178	biological_process	negative regulation of adipose tissue development
E	1904263	biological_process	positive regulation of TORC1 signaling
E	1904415	biological_process	regulation of xenophagy
E	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
E	2000001	biological_process	regulation of DNA damage checkpoint
E	2000036	biological_process	regulation of stem cell population maintenance
E	2000104	biological_process	negative regulation of DNA-templated DNA replication
F	0000082	biological_process	G1/S transition of mitotic cell cycle
F	0000209	biological_process	protein polyubiquitination
F	0000278	biological_process	mitotic cell cycle
F	0000922	cellular_component	spindle pole
F	0001822	biological_process	kidney development
F	0004842	molecular_function	ubiquitin-protein transferase activity
F	0005112	molecular_function	Notch binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005794	cellular_component	Golgi apparatus
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005827	cellular_component	polar microtubule
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006513	biological_process	protein monoubiquitination
F	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
F	0006915	biological_process	apoptotic process
F	0006950	biological_process	response to stress
F	0006954	biological_process	inflammatory response
F	0007080	biological_process	mitotic metaphase chromosome alignment
F	0007165	biological_process	signal transduction
F	0007229	biological_process	integrin-mediated signaling pathway
F	0008284	biological_process	positive regulation of cell population proliferation
F	0010467	biological_process	gene expression
F	0010468	biological_process	regulation of gene expression
F	0016020	cellular_component	membrane
F	0016192	biological_process	vesicle-mediated transport
F	0016477	biological_process	cell migration
F	0016567	biological_process	protein ubiquitination
F	0017145	biological_process	stem cell division
F	0030030	biological_process	cell projection organization
F	0030163	biological_process	protein catabolic process
F	0030332	molecular_function	cyclin binding
F	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
F	0031208	molecular_function	POZ domain binding
F	0031398	biological_process	positive regulation of protein ubiquitination
F	0031461	cellular_component	cullin-RING ubiquitin ligase complex
F	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
F	0031514	cellular_component	motile cilium
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0031648	biological_process	protein destabilization
F	0032467	biological_process	positive regulation of cytokinesis
F	0032480	biological_process	negative regulation of type I interferon production
F	0034599	biological_process	cellular response to oxidative stress
F	0035024	biological_process	negative regulation of Rho protein signal transduction
F	0036126	cellular_component	sperm flagellum
F	0040016	biological_process	embryonic cleavage
F	0042802	molecular_function	identical protein binding
F	0043149	biological_process	stress fiber assembly
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
F	0048208	biological_process	COPII vesicle coating
F	0051301	biological_process	cell division
F	0051865	biological_process	protein autoubiquitination
F	0061630	molecular_function	ubiquitin protein ligase activity
F	0070062	cellular_component	extracellular exosome
F	0070936	biological_process	protein K48-linked ubiquitination
F	0071230	biological_process	cellular response to amino acid stimulus
F	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
F	0072686	cellular_component	mitotic spindle
F	0080090	biological_process	regulation of primary metabolic process
F	0097193	biological_process	intrinsic apoptotic signaling pathway
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0140252	biological_process	regulation protein catabolic process at postsynapse
F	0160072	molecular_function	ubiquitin ligase complex scaffold activity
F	1900076	biological_process	regulation of cellular response to insulin stimulus
F	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
F	1904263	biological_process	positive regulation of TORC1 signaling
G	0000209	biological_process	protein polyubiquitination
G	0001678	biological_process	intracellular glucose homeostasis
G	0001784	molecular_function	phosphotyrosine residue binding
G	0005068	molecular_function	transmembrane receptor protein tyrosine kinase adaptor activity
G	0005096	molecular_function	GTPase activator activity
G	0005158	molecular_function	insulin receptor binding
G	0005159	molecular_function	insulin-like growth factor receptor binding
G	0005168	molecular_function	neurotrophin TRKA receptor binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005801	cellular_component	cis-Golgi network
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005911	cellular_component	cell-cell junction
G	0005942	cellular_component	phosphatidylinositol 3-kinase complex
G	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
G	0006955	biological_process	immune response
G	0007165	biological_process	signal transduction
G	0008286	biological_process	insulin receptor signaling pathway
G	0010592	biological_process	positive regulation of lamellipodium assembly
G	0015031	biological_process	protein transport
G	0016020	cellular_component	membrane
G	0019207	molecular_function	kinase regulator activity
G	0019209	molecular_function	kinase activator activity
G	0019221	biological_process	cytokine-mediated signaling pathway
G	0019903	molecular_function	protein phosphatase binding
G	0030183	biological_process	B cell differentiation
G	0030217	biological_process	T cell differentiation
G	0032869	biological_process	cellular response to insulin stimulus
G	0033120	biological_process	positive regulation of RNA splicing
G	0034143	biological_process	regulation of toll-like receptor 4 signaling pathway
G	0034446	biological_process	substrate adhesion-dependent cell spreading
G	0034976	biological_process	response to endoplasmic reticulum stress
G	0035014	molecular_function	phosphatidylinositol 3-kinase regulator activity
G	0035655	biological_process	interleukin-18-mediated signaling pathway
G	0036312	molecular_function	phosphatidylinositol 3-kinase regulatory subunit binding
G	0042267	biological_process	natural killer cell mediated cytotoxicity
G	0042307	biological_process	positive regulation of protein import into nucleus
G	0043066	biological_process	negative regulation of apoptotic process
G	0043125	molecular_function	ErbB-3 class receptor binding
G	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
G	0043548	molecular_function	phosphatidylinositol 3-kinase binding
G	0043559	molecular_function	insulin binding
G	0043560	molecular_function	insulin receptor substrate binding
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046326	biological_process	positive regulation of D-glucose import
G	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
G	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
G	0046982	molecular_function	protein heterodimerization activity
G	0048009	biological_process	insulin-like growth factor receptor signaling pathway
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0048661	biological_process	positive regulation of smooth muscle cell proliferation
G	0050821	biological_process	protein stabilization
G	0051491	biological_process	positive regulation of filopodium assembly
G	0051497	biological_process	negative regulation of stress fiber assembly
G	0052742	molecular_function	phosphatidylinositol kinase activity
G	0060396	biological_process	growth hormone receptor signaling pathway
G	0061470	biological_process	T follicular helper cell differentiation
G	0120183	biological_process	positive regulation of focal adhesion disassembly
G	0140767	molecular_function	enzyme-substrate adaptor activity
G	0141038	molecular_function	phosphatidylinositol 3-kinase activator activity
G	1900103	biological_process	positive regulation of endoplasmic reticulum unfolded protein response
G	1903078	biological_process	positive regulation of protein localization to plasma membrane
G	1990578	cellular_component	perinuclear endoplasmic reticulum membrane
H	0000209	biological_process	protein polyubiquitination
H	0001678	biological_process	intracellular glucose homeostasis
H	0001784	molecular_function	phosphotyrosine residue binding
H	0005068	molecular_function	transmembrane receptor protein tyrosine kinase adaptor activity
H	0005096	molecular_function	GTPase activator activity
H	0005158	molecular_function	insulin receptor binding
H	0005159	molecular_function	insulin-like growth factor receptor binding
H	0005168	molecular_function	neurotrophin TRKA receptor binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005801	cellular_component	cis-Golgi network
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005911	cellular_component	cell-cell junction
H	0005942	cellular_component	phosphatidylinositol 3-kinase complex
H	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
H	0006955	biological_process	immune response
H	0007165	biological_process	signal transduction
H	0008286	biological_process	insulin receptor signaling pathway
H	0010592	biological_process	positive regulation of lamellipodium assembly
H	0015031	biological_process	protein transport
H	0016020	cellular_component	membrane
H	0019207	molecular_function	kinase regulator activity
H	0019209	molecular_function	kinase activator activity
H	0019221	biological_process	cytokine-mediated signaling pathway
H	0019903	molecular_function	protein phosphatase binding
H	0030183	biological_process	B cell differentiation
H	0030217	biological_process	T cell differentiation
H	0032869	biological_process	cellular response to insulin stimulus
H	0033120	biological_process	positive regulation of RNA splicing
H	0034143	biological_process	regulation of toll-like receptor 4 signaling pathway
H	0034446	biological_process	substrate adhesion-dependent cell spreading
H	0034976	biological_process	response to endoplasmic reticulum stress
H	0035014	molecular_function	phosphatidylinositol 3-kinase regulator activity
H	0035655	biological_process	interleukin-18-mediated signaling pathway
H	0036312	molecular_function	phosphatidylinositol 3-kinase regulatory subunit binding
H	0042267	biological_process	natural killer cell mediated cytotoxicity
H	0042307	biological_process	positive regulation of protein import into nucleus
H	0043066	biological_process	negative regulation of apoptotic process
H	0043125	molecular_function	ErbB-3 class receptor binding
H	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
H	0043548	molecular_function	phosphatidylinositol 3-kinase binding
H	0043559	molecular_function	insulin binding
H	0043560	molecular_function	insulin receptor substrate binding
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0046326	biological_process	positive regulation of D-glucose import
H	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
H	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
H	0046982	molecular_function	protein heterodimerization activity
H	0048009	biological_process	insulin-like growth factor receptor signaling pathway
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0048661	biological_process	positive regulation of smooth muscle cell proliferation
H	0050821	biological_process	protein stabilization
H	0051491	biological_process	positive regulation of filopodium assembly
H	0051497	biological_process	negative regulation of stress fiber assembly
H	0052742	molecular_function	phosphatidylinositol kinase activity
H	0060396	biological_process	growth hormone receptor signaling pathway
H	0061470	biological_process	T follicular helper cell differentiation
H	0120183	biological_process	positive regulation of focal adhesion disassembly
H	0140767	molecular_function	enzyme-substrate adaptor activity
H	0141038	molecular_function	phosphatidylinositol 3-kinase activator activity
H	1900103	biological_process	positive regulation of endoplasmic reticulum unfolded protein response
H	1903078	biological_process	positive regulation of protein localization to plasma membrane
H	1990578	cellular_component	perinuclear endoplasmic reticulum membrane

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkrIegLIEReYLaRtpedrkvYtYvA

Chain	Residue	Details
C	ILE741-ALA768

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	90
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	134
Details	Domain: {"description":"BTB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00037","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	192
Details	Domain: {"description":"BACK","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	96
Details	Repeat: {"description":"Kelch 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	76
Details	Repeat: {"description":"Kelch 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	92
Details	Repeat: {"description":"Kelch 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	190
Details	Domain: {"description":"SH2 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	188
Details	Domain: {"description":"SH2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P26450","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	124
Details	Domain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	42
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	32
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"UniProtKB","id":"Q13616","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---