8H4V

Mincle CRD complex with PGL trisaccharide

Summary for 8H4V

• Entry DOI: 10.2210/pdb8h4v/pdb
• Descriptor: C-type lectin domain family 4 member E, (2~{R},3~{R},4~{S},5~{S},6~{R})-6-(methoxymethyl)oxane-2,3,4,5-tetrol-(1-4)-6-deoxy-2,3-di-O-methyl-alpha-L-mannopyranose-(1-2)-3-O-methyl-alpha-L-rhamnopyranose, CALCIUM ION (3 entities in total)
• Functional Keywords: immune receptor, innate immunity, c-type lectin receptor, mycobacterium leprae, sugar binding protein
• Biological source: Bos taurus (cattle)
• Total number of polymer chains: 2
• Total formula weight: 36184.61

Authors

Ishizuka, S.,Nagae, M.,Yamasaki, S. (deposition date: 2022-10-11, release date: 2023-08-09)

• Primary citation: Ishizuka, S.,van Dijk, J.H.M.,Kawakita, T.,Miyamoto, Y.,Maeda, Y.,Goto, M.,Le Calvez, G.,Groot, L.M.,Witte, M.D.,Minnaard, A.J.,van der Marel, G.A.,Ato, M.,Nagae, M.,Codee, J.D.C.,Yamasaki, S.; PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand.; Acs Cent.Sci., 9:1388-1399, 2023; PubMed: 37521780; DOI: 10.1021/acscentsci.3c00040

Experimental method

X-RAY DIFFRACTION (2.4 Å)