3BCH
 
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7TQL
 | | CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B. | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Lapointe, C.P, Grosely, R, Sokabe, M, Alvarado, C, Wang, J, Montabana, E, Villa, N, Shin, B, Dever, T, Fraser, C, Fernandez, I.S, Puglisi, J.D. | | Deposit date: | 2022-01-26 | | Release date: | 2022-04-27 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.
Nature, 607, 2022
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8PPL
 | | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Schubert, K, Karousis, E.D, Ban, I, Lapointe, C.P, Leibundgut, M, Baeumlin, E, Kummerant, E, Scaiola, A, Schoenhut, T, Ziegelmueller, J, Puglisi, J.D, Muehlemann, O, Ban, N. | | Deposit date: | 2023-07-07 | | Release date: | 2023-10-18 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Universal features of Nsp1-mediated translational shutdown by coronaviruses.
Mol.Cell, 83, 2023
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4V6X
 | | Structure of the human 80S ribosome | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Anger, A.M, Armache, J.-P, Berninghausen, O, Habeck, M, Subklewe, M, Wilson, D.N, Beckmann, R. | | Deposit date: | 2013-02-27 | | Release date: | 2014-07-09 | | Last modified: | 2023-02-01 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | Structures of the human and Drosophila 80S ribosome.
Nature, 497, 2013
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6QZP
 | | High-resolution cryo-EM structure of the human 80S ribosome | | Descriptor: | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ... | | Authors: | Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P. | | Deposit date: | 2019-03-12 | | Release date: | 2019-04-24 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Visualization of chemical modifications in the human 80S ribosome structure.
Nature, 551, 2017
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4UG0
 | | STRUCTURE OF THE HUMAN 80S RIBOSOME | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S RIBOSOMAL PROTEIN, ... | | Authors: | Khatter, H, Myasnikov, A.G, Natchiar, S.K, Klaholz, B.P. | | Deposit date: | 2015-03-20 | | Release date: | 2015-06-10 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure of the human 80S ribosome
NATURE, 520, 2015
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5FLX
 | | Mammalian 40S HCV-IRES complex | | Descriptor: | 18S RRNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ... | | Authors: | Yamamoto, H, Collier, M, Loerke, J, Ismer, J, Schmidt, A, Hilal, T, Sprink, T, Yamamoto, K, Mielke, T, Burger, J, Shaikh, T.R, Dabrowski, M, Hildebrand, P.W, Scheerer, P, Spahn, C.M.T. | | Deposit date: | 2015-10-28 | | Release date: | 2015-12-23 | | Last modified: | 2017-08-30 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site RNA.
Embo J., 34, 2015
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5OA3
 | | Human 40S-eIF2D-re-initiation complex | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Weisser, M, Schaefer, T, Leibundgut, M, Boehringer, D, Aylett, C.H.S, Ban, N. | | Deposit date: | 2017-06-20 | | Release date: | 2017-08-09 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structural and Functional Insights into Human Re-initiation Complexes.
Mol. Cell, 67, 2017
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7K5I
 | | SARS-COV-2 nsp1 in complex with human 40S ribosome | | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | | Authors: | Wang, L, Shi, M, Wu, H. | | Deposit date: | 2020-09-16 | | Release date: | 2020-10-14 | | Last modified: | 2021-03-17 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism.
Biorxiv, 2020
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5LKS
 | | Structure-function insights reveal the human ribosome as a cancer target for antibiotics | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | Authors: | Myasnikov, A.G, Natchiar, S.K, Nebout, M, Hazemann, I, Imbert, V, Khatter, H, Peyron, J.-F, Klaholz, B.P. | | Deposit date: | 2016-07-23 | | Release date: | 2017-04-26 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Nat Commun, 7, 2016
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6XA1
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7XNY
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7XNX
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7CPV
 | | Cryo-EM structure of 80S ribosome from mouse testis | | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S13, ... | | Authors: | Huo, Y.G, He, X, Jiang, T, Qin, Y, Guo, X.J, Sha, J.H. | | Deposit date: | 2020-08-08 | | Release date: | 2022-02-02 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | A male germ-cell-specific ribosome controls male fertility.
Nature, 612, 2022
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7CPU
 | | Cryo-EM structure of 80S ribosome from mouse kidney | | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S13, ... | | Authors: | Huo, Y.G, He, X, Jiang, T, Qin, Y, Guo, X.J, Sha, J.H. | | Deposit date: | 2020-08-08 | | Release date: | 2022-02-02 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.82 Å) | | Cite: | A male germ-cell-specific ribosome controls male fertility.
Nature, 612, 2022
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5A2Q
 | | Structure of the HCV IRES bound to the human ribosome | | Descriptor: | 18S RRNA, HCV IRES, MAGNESIUM ION, ... | | Authors: | Quade, N, Leiundgut, M, Boehringer, D, Heuvel, J.v.d, Ban, N. | | Deposit date: | 2015-05-21 | | Release date: | 2015-07-15 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-Em Structure of Hepatitis C Virus Ires Bound to the Human Ribosome at 3.9 Angstrom Resolution
Nat.Commun., 6, 2015
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5AJ0
 | | Cryo electron microscopy of actively translating human polysomes (POST state). | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Behrmann, E, Loerke, J, Budkevich, T.V, Yamamoto, K, Schmidt, A, Penczek, P.A, Vos, M.R, Burger, J, Mielke, T, Scheerer, P, Spahn, C.M.T. | | Deposit date: | 2015-02-19 | | Release date: | 2015-05-20 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural Snapshots of Actively Translating Human Ribosomes
Cell(Cambridge,Mass.), 161, 2015
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5T2C
 | | CryoEM structure of the human ribosome at 3.6 Angstrom resolution | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | Authors: | Zhang, X, Lai, M, Zhou, Z.H. | | Deposit date: | 2016-08-23 | | Release date: | 2017-01-25 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Nat Commun, 7, 2016
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7LS2
 | | 80S ribosome from mouse bound to eEF2 (Class I) | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | Authors: | Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T. | | Deposit date: | 2021-02-17 | | Release date: | 2021-11-03 | | Last modified: | 2021-12-08 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Nat Commun, 12, 2021
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7LS1
 | | 80S ribosome from mouse bound to eEF2 (Class II) | | Descriptor: | 28S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T. | | Deposit date: | 2021-02-17 | | Release date: | 2021-11-03 | | Last modified: | 2021-12-08 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Nat Commun, 12, 2021
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5VYC
 | | Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1. | | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | | Authors: | Lomakin, I.B, Stolboushkina, E.A, Vaidya, A.T, Garber, M.B, Dmitriev, S.E, Steitz, T.A. | | Deposit date: | 2017-05-24 | | Release date: | 2017-07-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (6 Å) | | Cite: | Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.
Cell Rep, 20, 2017
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6IP6
 | | Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii) | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | | Deposit date: | 2018-11-02 | | Release date: | 2019-05-29 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | HCV IRES Captures an Actively Translating 80S Ribosome.
Mol.Cell, 74, 2019
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6IP8
 | | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | | Deposit date: | 2018-11-02 | | Release date: | 2019-05-29 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | HCV IRES Captures an Actively Translating 80S Ribosome.
Mol.Cell, 74, 2019
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6IP5
 | | Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | | Deposit date: | 2018-11-02 | | Release date: | 2019-05-29 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | HCV IRES Captures an Actively Translating 80S Ribosome.
Mol.Cell, 74, 2019
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7QP6
 | | Structure of the human 48S initiation complex in open state (h48S AUG open) | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Yi, S.-H, Petrychenko, V, Schliep, J.E, Goyal, A, Linden, A, Chari, A, Urlaub, H, Stark, H, Rodnina, M.V, Adio, S, Fischer, N. | | Deposit date: | 2022-01-03 | | Release date: | 2022-05-11 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Conformational rearrangements upon start codon recognition in human 48S translation initiation complex.
Nucleic Acids Res., 50, 2022
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