Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC)

This is a large structure.

Summary for 6OLI

EMDB information0526 0600 0599 0601 0596 0598 0597
Descriptor18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ... (87 entities in total)
Functional Keywordsselective stalling, drug-like molecule, human ribosome nascent chain complex, ribosome
Biological sourceHomo sapiens (Human)
Total number of polymer chains83
Total molecular weight3175983.5
Li, W.,Cate, J.H.D. (deposition date: 2019-04-16, release date: 2019-06-19)
Primary citation
Li, W.,Ward, F.R.,McClure, K.F.,Chang, S.T.,Montabana, E.,Liras, S.,Dullea, R.G.,Cate, J.H.D.
Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26:501-509, 2019
PubMed: 31160784 (PDB entries with the same primary citation)
DOI: 10.1038/s41594-019-0236-8
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone7 0.4% 2.6% 0.42MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures