6OLI
Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (S2) | 18S ribosomal RNA | polymer | 1714 | 553505.1 | 1 | Homo sapiens (Human) | ||
| 2 | B (SA) | 40S ribosomal protein SA | polymer | 221 | 24774.4 | 1 | UniProt (P08865) Pfam (PF00318) | Homo sapiens (Human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2 |
| 3 | C (SB) | 40S ribosomal protein S3a | polymer | 214 | 24888.3 | 1 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (Human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
| 4 | D (SD) | 40S ribosomal protein S3 | polymer | 226 | 25041.4 | 1 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | Homo sapiens (Human) | Small ribosomal subunit protein uS3 |
| 5 | E (SE) | 40S ribosomal protein S4, X isoform | polymer | 259 | 29292.5 | 1 | UniProt (P62701) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Homo sapiens (Human) | SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4 |
| 6 | F (SF) | 40S ribosomal protein S5 | polymer | 189 | 21327.7 | 1 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (Human) | Small ribosomal subunit protein uS7 |
| 7 | G (SH) | 40S ribosomal protein S7 | polymer | 189 | 21603.2 | 1 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (Human) | Small ribosomal subunit protein eS7 |
| 8 | H (SI) | 40S ribosomal protein S8 | polymer | 204 | 23816.8 | 1 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (Human) | Small ribosomal subunit protein eS8 |
| 9 | I (SK) | 40S ribosomal protein S10 | polymer | 98 | 11774.0 | 1 | UniProt (P46783) Pfam (PF03501) | Homo sapiens (Human) | Small ribosomal subunit protein eS10 |
| 10 | J (SL) | 40S ribosomal protein S11 | polymer | 153 | 17786.0 | 1 | UniProt (P62280) Pfam (PF16205) Pfam (PF00366) | Homo sapiens (Human) | Small ribosomal subunit protein uS17 |
| 11 | K (SP) | 40S ribosomal protein S15 | polymer | 127 | 14931.6 | 1 | UniProt (P62841) Pfam (PF00203) | Homo sapiens (Human) | RIG protein,Small ribosomal subunit protein uS19 |
| 12 | L (SQ) | 40S ribosomal protein S16 | polymer | 146 | 16477.4 | 1 | UniProt (P62249) Pfam (PF00380) | Homo sapiens (Human) | Small ribosomal subunit protein uS9 |
| 13 | M (SR) | 40S ribosomal protein S17 | polymer | 134 | 15447.0 | 1 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (Human) | Small ribosomal subunit protein eS17 |
| 14 | N (SS) | 40S ribosomal protein S18 | polymer | 145 | 17029.8 | 1 | UniProt (P62269) Pfam (PF00416) | Homo sapiens (Human) | Ke-3,Ke3,Small ribosomal subunit protein uS13 |
| 15 | O (ST) | 40S ribosomal protein S19 | polymer | 143 | 15822.2 | 1 | UniProt (P39019) Pfam (PF01090) | Homo sapiens (Human) | Small ribosomal subunit protein eS19 |
| 16 | P (SU) | 40S ribosomal protein S20 | polymer | 104 | 11765.9 | 1 | UniProt (P60866) Pfam (PF00338) | Homo sapiens (Human) | Small ribosomal subunit protein uS10 |
| 17 | Q (SV) | 40S ribosomal protein S21 | polymer | 82 | 8977.2 | 1 | UniProt (P63220) Pfam (PF01249) | Homo sapiens (Human) | Small ribosomal subunit protein eS21 |
| 18 | R (SX) | 40S ribosomal protein S23 | polymer | 141 | 15626.4 | 1 | UniProt (P62266) Pfam (PF00164) | Homo sapiens (Human) | Small ribosomal subunit protein uS12 |
| 19 | S (Sa) | 40S ribosomal protein S26 | polymer | 102 | 11742.9 | 1 | UniProt (P62854) Pfam (PF01283) | Homo sapiens (Human) | Small ribosomal subunit protein eS26 |
| 20 | T (Sc) | 40S ribosomal protein S28 | polymer | 64 | 7263.4 | 1 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (Human) | Small ribosomal subunit protein eS28 |
| 21 | U (Sd) | 40S ribosomal protein S29 | polymer | 55 | 6559.6 | 1 | UniProt (P62273) Pfam (PF00253) | Homo sapiens (Human) | Small ribosomal subunit protein uS14 |
| 22 | V (Sg) | Receptor of activated protein C kinase 1 | polymer | 312 | 34568.0 | 1 | UniProt (P63244) Pfam (PF00400) | Homo sapiens (Human) | Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1 |
| 23 | W (SC) | 40S ribosomal protein S2 | polymer | 220 | 24330.7 | 1 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | Homo sapiens (Human) | 40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5 |
| 24 | X (SG) | 40S ribosomal protein S6 | polymer | 237 | 27471.5 | 1 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (Human) | Phosphoprotein NP33,Small ribosomal subunit protein eS6 |
| 25 | Y (SJ) | 40S ribosomal protein S9 | polymer | 185 | 21649.6 | 1 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (Human) | Small ribosomal subunit protein uS4 |
| 26 | Z (SM) | 40S ribosomal protein S12 | polymer | 118 | 13217.4 | 1 | UniProt (P25398) Pfam (PF01248) | Homo sapiens (Human) | Small ribosomal subunit protein eS12 |
| 27 | AA (SN) | 40S ribosomal protein S13 | polymer | 150 | 17128.2 | 1 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (Human) | Small ribosomal subunit protein uS15 |
| 28 | BA (SO) | 40S ribosomal protein S14 | polymer | 137 | 14657.8 | 1 | UniProt (P62263) Pfam (PF00411) | Homo sapiens (Human) | Small ribosomal subunit protein uS11 |
| 29 | CA (SW) | 40S ribosomal protein S15a | polymer | 129 | 14734.4 | 1 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (Human) | Small ribosomal subunit protein uS8 |
| 30 | DA (SY) | 40S ribosomal protein S24 | polymer | 131 | 15203.0 | 1 | UniProt (P62847) Pfam (PF01282) | Homo sapiens (Human) | Small ribosomal subunit protein eS24 |
| 31 | EA (SZ) | 40S ribosomal protein S25 | polymer | 73 | 8253.8 | 1 | UniProt (P62851) Pfam (PF03297) | Homo sapiens (Human) | Small ribosomal subunit protein eS25 |
| 32 | FA (Sb) | 40S ribosomal protein S27 | polymer | 82 | 9210.8 | 1 | UniProt (P42677) Pfam (PF01667) | Homo sapiens (Human) | Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27 |
| 33 | GA (Se) | 40S ribosomal protein S30 | polymer | 57 | 6452.7 | 1 | UniProt (E9PR30) Pfam (PF04758) UniProt (by SIFTS) (P62861) | Homo sapiens (Human) | |
| 34 | HA (Sf) | 40S ribosomal protein S27a | polymer | 67 | 7884.3 | 1 | UniProt (P62979) Pfam (PF01599) | Homo sapiens (Human) | Ubiquitin carboxyl extension protein 80 |
| 35 | IA (A) | 60S ribosomal protein L8 | polymer | 252 | 27456.2 | 1 | UniProt (P62917) Pfam (PF00181) Pfam (PF03947) | Homo sapiens (Human) | Large ribosomal subunit protein uL2 |
| 36 | JA (B) | 60S ribosomal protein L3 | polymer | 397 | 45564.4 | 1 | UniProt (P39023) Pfam (PF00297) | Homo sapiens (Human) | HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3 |
| 37 | KA (C) | 60S ribosomal protein L4 | polymer | 363 | 41171.5 | 1 | UniProt (P36578) Pfam (PF00573) Pfam (PF14374) | Homo sapiens (Human) | 60S ribosomal protein L1,Large ribosomal subunit protein uL4 |
| 38 | LA (D) | 5.8S ribosomal RNA | polymer | 157 | 50449.8 | 1 | Homo sapiens (Human) | ||
| 39 | MA (E) | 5S ribosomal RNA | polymer | 121 | 38998.1 | 1 | Homo sapiens (Human) | ||
| 40 | NA (F) | 60S ribosomal protein L5 | polymer | 294 | 34091.4 | 1 | UniProt (P46777) Pfam (PF17144) Pfam (PF14204) | Homo sapiens (Human) | Large ribosomal subunit protein uL18 |
| 41 | OA (G) | 60S ribosomal protein L6 | polymer | 247 | 28378.8 | 1 | UniProt (Q02878) Pfam (PF03868) Pfam (PF01159) | Homo sapiens (Human) | Large ribosomal subunit protein eL6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107 |
| 42 | PA (H) | 60S ribosomal protein L7 | polymer | 225 | 26590.7 | 1 | UniProt (P18124) Pfam (PF08079) Pfam (PF00327) | Homo sapiens (Human) | Large ribosomal subunit protein uL30 |
| 43 | QA (I) | 60S ribosomal protein L7a | polymer | 234 | 26724.6 | 1 | UniProt (P62424) Pfam (PF01248) | Homo sapiens (Human) | Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3 |
| 44 | RA (J) | 60S ribosomal protein L9 | polymer | 191 | 21770.4 | 1 | UniProt (P32969) Pfam (PF00347) | Homo sapiens (Human) | Large ribosomal subunit protein uL6 |
| 45 | SA (K) | 60S ribosomal protein L10 | polymer | 211 | 24381.8 | 1 | UniProt (P27635) Pfam (PF00252) | Homo sapiens (Human) | Laminin receptor homolog,Large ribosomal subunit protein uL16,Protein QM,Ribosomal protein L10,Tumor suppressor QM |
| 46 | TA (L) | 60S ribosomal protein L11 | polymer | 169 | 19270.3 | 1 | UniProt (P62913) Pfam (PF00281) Pfam (PF00673) | Homo sapiens (Human) | CLL-associated antigen KW-12,Large ribosomal subunit protein uL5 |
| 47 | UA (M) | 60S ribosomal protein L13 | polymer | 205 | 23574.7 | 1 | UniProt (P26373) Pfam (PF01294) | Homo sapiens (Human) | Breast basic conserved protein 1,Large ribosomal subunit protein eL13 |
| 48 | VA (N) | 60S ribosomal protein L14 | polymer | 139 | 16220.3 | 1 | UniProt (P50914) Pfam (PF01929) | Homo sapiens (Human) | CAG-ISL 7,Large ribosomal subunit protein eL14 |
| 49 | WA (O) | 60S ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (P61313) Pfam (PF00827) | Homo sapiens (Human) | Large ribosomal subunit protein eL15 |
| 50 | XA (P) | 60S ribosomal protein L13a | polymer | 195 | 22820.4 | 1 | UniProt (P40429) Pfam (PF00572) | Homo sapiens (Human) | 23 kDa highly basic protein,Large ribosomal subunit protein uL13 |
| 51 | YA (Q) | 60S ribosomal protein L17 | polymer | 153 | 17757.6 | 1 | UniProt (P18621) Pfam (PF00237) | Homo sapiens (Human) | 60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1 |
| 52 | ZA (R) | 60S ribosomal protein L18 | polymer | 187 | 21556.5 | 1 | UniProt (Q07020) Pfam (PF17135) | Homo sapiens (Human) | Large ribosomal subunit protein eL18 |
| 53 | AB (S) | 60S ribosomal protein L19 | polymer | 181 | 21742.1 | 1 | UniProt (P84098) Pfam (PF01280) | Homo sapiens (Human) | Large ribosomal subunit protein eL19 |
| 54 | BB (T) | 60S ribosomal protein L18a | polymer | 175 | 20661.3 | 1 | UniProt (Q02543) Pfam (PF01775) | Homo sapiens (Human) | Large ribosomal subunit protein eL20 |
| 55 | CB (U) | 60S ribosomal protein L21 | polymer | 157 | 18276.5 | 1 | UniProt (P46778) Pfam (PF01157) | Homo sapiens (Human) | Large ribosomal subunit protein eL21 |
| 56 | DB (V) | 60S ribosomal protein L22 | polymer | 99 | 11481.2 | 1 | UniProt (P35268) Pfam (PF01776) | Homo sapiens (Human) | EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15,Large ribosomal subunit protein eL22 |
| 57 | EB (W) | 60S ribosomal protein L23 | polymer | 129 | 13828.3 | 1 | UniProt (Q9BTQ7) Pfam (PF00238) UniProt (by SIFTS) (P62829) | Homo sapiens (Human) | |
| 58 | FB (X) | 60S ribosomal protein L24 | polymer | 61 | 7253.4 | 1 | UniProt (P83731) Pfam (PF01246) | Homo sapiens (Human) | 60S ribosomal protein L30,Large ribosomal subunit protein eL24 |
| 59 | GB (Y) | 60S ribosomal protein L23a | polymer | 117 | 13614.0 | 1 | UniProt (P62750) Pfam (PF03939) Pfam (PF00276) | Homo sapiens (Human) | Large ribosomal subunit protein uL23 |
| 60 | HB (Z) | 60S ribosomal protein L26 | polymer | 134 | 15891.8 | 1 | UniProt (P61254) Pfam (PF16906) Pfam (PF00467) | Homo sapiens (Human) | Large ribosomal subunit protein uL24 |
| 61 | IB (a) | 60S ribosomal protein L27 | polymer | 134 | 15647.6 | 1 | UniProt (P61353) Pfam (PF00467) Pfam (PF01777) | Homo sapiens (Human) | Large ribosomal subunit protein eL27 |
| 62 | JB (b) | 60S ribosomal protein L27a | polymer | 147 | 16473.3 | 1 | UniProt (P46776) Pfam (PF00828) | Homo sapiens (Human) | Large ribosomal subunit protein uL15 |
| 63 | KB (c) | 60S ribosomal protein L29 | polymer | 121 | 13965.8 | 1 | UniProt (P47914) Pfam (PF01779) | Homo sapiens (Human) | Cell surface heparin-binding protein HIP,Large ribosomal subunit protein eL29 |
| 64 | LB (d) | 60S ribosomal protein L30 | polymer | 103 | 11500.6 | 1 | UniProt (P62888) Pfam (PF01248) | Homo sapiens (Human) | Large ribosomal subunit protein eL30 |
| 65 | MB (e) | 60S ribosomal protein L31 | polymer | 106 | 12506.6 | 1 | UniProt (P62899) Pfam (PF01198) | Homo sapiens (Human) | Large ribosomal subunit protein eL31 |
| 66 | NB (f) | 60S ribosomal protein L32 | polymer | 129 | 15179.2 | 1 | UniProt (P62910) Pfam (PF01655) | Homo sapiens (Human) | Large ribosomal subunit protein eL32 |
| 67 | OB (g) | 60S ribosomal protein L35a | polymer | 109 | 12433.5 | 1 | UniProt (P18077) Pfam (PF01247) | Homo sapiens (Human) | Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33 |
| 68 | PB (h) | 60S ribosomal protein L34 | polymer | 114 | 12994.6 | 1 | UniProt (P49207) Pfam (PF01199) | Homo sapiens (Human) | Large ribosomal subunit protein eL34 |
| 69 | QB (i) | 60S ribosomal protein L35 | polymer | 122 | 14462.4 | 1 | UniProt (P42766) Pfam (PF00831) | Homo sapiens (Human) | Large ribosomal subunit protein uL29 |
| 70 | RB (j) | 60S ribosomal protein L36 | polymer | 97 | 11373.7 | 1 | UniProt (Q9Y3U8) Pfam (PF01158) | Homo sapiens (Human) | Large ribosomal subunit protein eL36 |
| 71 | SB (k) | 60S ribosomal protein L37 | polymer | 84 | 9864.6 | 1 | UniProt (P61927) Pfam (PF01907) | Homo sapiens (Human) | G1.16,Large ribosomal subunit protein eL37 |
| 72 | TB (l) | 60S ribosomal protein L38 | polymer | 69 | 8107.8 | 1 | UniProt (P63173) Pfam (PF01781) | Homo sapiens (Human) | Large ribosomal subunit protein eL38 |
| 73 | UB (m) | 60S ribosomal protein L39 | polymer | 50 | 6295.6 | 1 | UniProt (P62891) Pfam (PF00832) | Homo sapiens (Human) | Large ribosomal subunit protein eL39 |
| 74 | VB (n) | 60S ribosomal protein L40 | polymer | 50 | 5957.2 | 1 | UniProt (P62987) Pfam (PF01020) | Homo sapiens (Human) | CEP52,Ubiquitin A-52 residue ribosomal protein fusion product 1 |
| 75 | WB (o) | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 1 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (Human) | HG12,Large ribosomal subunit protein eL41 |
| 76 | XB (p) | 60S ribosomal protein L36a | polymer | 105 | 12345.8 | 1 | UniProt (P83881) Pfam (PF00935) | Homo sapiens (Human) | 60S ribosomal protein L44,Cell growth-inhibiting gene 15 protein,Cell migration-inducing gene 6 protein,Large ribosomal subunit protein eL42 |
| 77 | YB (q) | 60S ribosomal protein L37a | polymer | 91 | 10168.2 | 1 | UniProt (P61513) Pfam (PF01780) | Homo sapiens (Human) | Large ribosomal subunit protein eL43 |
| 78 | ZB (r) | 60S ribosomal protein L28 | polymer | 122 | 13991.4 | 1 | UniProt (P46779) Pfam (PF01778) | Homo sapiens (Human) | Large ribosomal subunit protein eL28 |
| 79 | AC (t) | 28S ribosomal RNA | polymer | 3607 | 1168718.5 | 1 | Homo sapiens (Human) | ||
| 80 | BC (u) | tRNA | polymer | 76 | 24414.5 | 1 | Homo sapiens (Human) | ||
| 81 | CC (v) | tRNA | polymer | 76 | 24436.5 | 1 | Homo sapiens (Human) | ||
| 82 | DC (w) | mRNA | polymer | 10 | 3193.9 | 1 | Homo sapiens (Human) | ||
| 83 | EC (y) | Nascent chain | polymer | 36 | 3081.8 | 1 | Homo sapiens (Human) | ||
| 84 | AD, BD, CD, ED, FC... (E, O, b, o, S2...) | MAGNESIUM ION | non-polymer | 24.3 | 31 | Chemie (MG) | |||
| 85 | DD, FD, GC, GD, IC... (k, p, S2, q, Sa...) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 86 | QD (t) | N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide | non-polymer | 433.9 | 1 | Chemie (MVM) | |||
| 87 | AE, RD, SD, TD, UD... (u, S2, SP, SQ, SR...) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
SM: 15 - 132 (UniProt: P25398)
| PDB | External Database | Details |
|---|---|---|
| Gln 52 | Leu 52 | conflict |
| Leu 69 | Cys 69 | conflict |
| Asn 99 | Lys 99 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 83 |
| Total formula weight | 3174403.7 | |
| Non-Polymers* | Number of molecules | 38 |
| Total formula weight | 1579.8 | |
| All* | Total formula weight | 3175983.5 |
