6OM0

Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs

This is a large structure.

Summary for 6OM0

EMDB information0596 0600 0599 0601 0526 0598 0597
Descriptor18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ... (87 entities in total)
Functional Keywordsselective stalling, drug-like molecule, human ribosome nascent chain complex, ribosome
Biological sourceHomo sapiens (Human)
Total number of polymer chains83
Total molecular weight3175175.79
Authors
Li, W.,Cate, J.H.D. (deposition date: 2019-04-17, release date: 2019-06-19)
Primary citation
Li, W.,Ward, F.R.,McClure, K.F.,Chang, S.T.,Montabana, E.,Liras, S.,Dullea, R.G.,Cate, J.H.D.
Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26:501-509, 2019
PubMed: 31160784 (PDB entries with the same primary citation)
DOI: 10.1038/s41594-019-0236-8
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone5 0.5% 2.4% 0.44MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures