2H62
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h62 by Molmil](/molmil-images/mine/2h62) | Crystal structure of a ternary ligand-receptor complex of BMP-2 | Descriptor: | Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA | Authors: | Mueller, T.D. | Deposit date: | 2006-05-30 | Release date: | 2007-04-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor. Bmc Struct.Biol., 7, 2007
|
|
1REW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1rew by Molmil](/molmil-images/mine/1rew) | Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor | Descriptor: | bone morphogenetic protein 2, bone morphogenetic protein receptor type IA | Authors: | Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D. | Deposit date: | 2003-11-07 | Release date: | 2004-05-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.863 Å) | Cite: | Molecular recognition of BMP-2 and BMP receptor IA. Nat.Struct.Mol.Biol., 11, 2004
|
|
4N1D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4n1d by Molmil](/molmil-images/mine/4n1d) | Nodal/BMP2 chimera NB250 | Descriptor: | Nodal/BMP2 chimera protein | Authors: | Esquivies, L. | Deposit date: | 2013-10-04 | Release date: | 2013-12-04 | Last modified: | 2017-07-26 | Method: | X-RAY DIFFRACTION (1.912 Å) | Cite: | Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure. J.Biol.Chem., 289, 2014
|
|
2H64
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h64 by Molmil](/molmil-images/mine/2h64) | |
2ARP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2arp by Molmil](/molmil-images/mine/2arp) | Activin A in complex with Fs12 fragment of follistatin | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Follistatin, GLYCEROL, ... | Authors: | Harrington, A.E, Morris-Triggs, S.A, Ruotolo, B.T, Robinson, C.V, Ohnuma, S, Hyvonen, M. | Deposit date: | 2005-08-21 | Release date: | 2006-03-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the inhibition of activin signalling by follistatin Embo J., 25, 2006
|
|
2ARV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2arv by Molmil](/molmil-images/mine/2arv) | Structure of human Activin A | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, GLYCEROL, Inhibin beta A chain, ... | Authors: | Harrington, A.E, Morris-Triggs, S.A, Ruotolo, B.T, Robinson, C.V, Ohnuma, S, Hyvonen, M. | Deposit date: | 2005-08-22 | Release date: | 2006-03-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the inhibition of activin signalling by follistatin Embo J., 25, 2006
|
|
6Y6N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y6n by Molmil](/molmil-images/mine/6y6n) | Structure of mature activin A with small molecule 2 | Descriptor: | (3~{R})-3,4-dimethyl-3-propyl-1~{H}-1,4-benzodiazepine-2,5-dione, Inhibin beta A chain, SULFATE ION | Authors: | McLoughlin, J.D, Brear, P.B, Reinhardt, T, Spring, D.R, Hyvonen, M. | Deposit date: | 2020-02-26 | Release date: | 2021-01-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion Chem Sci, 11, 2020
|
|
6Y6O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y6o by Molmil](/molmil-images/mine/6y6o) | Structure of mature activin A with small molecule 42 | Descriptor: | (3~{R})-4-ethyl-3-methyl-3-propyl-1~{H}-1,4-benzodiazepine-2,5-dione, Inhibin beta A chain, SULFATE ION | Authors: | McLoughlin, J.D, Brear, P.B, Reinhardt, T, Spring, D.R, Hyvonen, M. | Deposit date: | 2020-02-26 | Release date: | 2021-02-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion Chem Sci, 11, 2020
|
|
4MID
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mid by Molmil](/molmil-images/mine/4mid) | Crystal Structure of Activin A/BMP2 chimera | Descriptor: | AB204 Activin A/BMP2 chimera | Authors: | Esquivies, L. | Deposit date: | 2013-08-30 | Release date: | 2014-05-07 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2.139 Å) | Cite: | An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2. J.Bone Miner.Res., 29, 2014
|
|
2GOO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2goo by Molmil](/molmil-images/mine/2goo) | Ternary Complex of BMP-2 bound to BMPR-Ia-ECD and ActRII-ECD | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, Activin receptor type 2A, Bone morphogenetic protein 2, ... | Authors: | Allendorph, G.P, Choe, S. | Deposit date: | 2006-04-13 | Release date: | 2006-05-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the ternary signaling complex of a TGF-beta superfamily member. Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
1S4Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1s4y by Molmil](/molmil-images/mine/1s4y) | Crystal structure of the activin/actrIIb extracellular domain | Descriptor: | Activin receptor type IIB precursor, Inhibin beta A chain | Authors: | Greenwald, J, Vega, M.E, Allendorph, G.P, Fischer, W.H, Vale, W, Choe, S, Joint Center for Structural Genomics (JCSG) | Deposit date: | 2004-01-19 | Release date: | 2004-08-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A Flexible Activin Explains the Membrane-Dependent Cooperative Assembly of TGF-beta Family Receptors. Mol.Cell, 15, 2004
|
|
5HLY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hly by Molmil](/molmil-images/mine/5hly) | |
4UI1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ui1 by Molmil](/molmil-images/mine/4ui1) | Crystal structure of the human RGMC-BMP2 complex | Descriptor: | 1,2-ETHANEDIOL, BONE MORPHOGENETIC PROTEIN 2, CHLORIDE ION, ... | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | Deposit date: | 2015-03-27 | Release date: | 2015-05-06 | Last modified: | 2015-06-17 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein. Nat.Struct.Mol.Biol., 22, 2015
|
|
2QJ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qj9 by Molmil](/molmil-images/mine/2qj9) | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B1 | Descriptor: | Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA | Authors: | Kotzsch, A, Mueller, T.D. | Deposit date: | 2007-07-06 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
|
|
3B4V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3b4v by Molmil](/molmil-images/mine/3b4v) | X-Ray structure of Activin in complex with FSTL3 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Inhibin beta A chain, ... | Authors: | Thompson, T.B. | Deposit date: | 2007-10-24 | Release date: | 2008-09-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. J.Biol.Chem., 283, 2008
|
|
2QJB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qjb by Molmil](/molmil-images/mine/2qjb) | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB | Descriptor: | Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, CHLORIDE ION | Authors: | Kotzsch, A, Mueller, T.D. | Deposit date: | 2007-07-06 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
|
|
2QJA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qja by Molmil](/molmil-images/mine/2qja) | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B12 | Descriptor: | Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA | Authors: | Kotzsch, A, Mueller, T.D. | Deposit date: | 2007-07-06 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
|
|
1REU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1reu by Molmil](/molmil-images/mine/1reu) | Structure of the bone morphogenetic protein 2 mutant L51P | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, bone morphogenetic protein 2 | Authors: | Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D. | Deposit date: | 2003-11-07 | Release date: | 2004-05-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Molecular recognition of BMP-2 and BMP receptor IA. Nat.Struct.Mol.Biol., 11, 2004
|
|
6OMN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6omn by Molmil](/molmil-images/mine/6omn) | Glycosylated BMP2 homodimer | Descriptor: | Bone morphogenetic protein 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Juo, Z.S, Seeherman, H. | Deposit date: | 2019-04-19 | Release date: | 2019-05-08 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. Sci Transl Med, 11, 2019
|
|
3BMP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3bmp by Molmil](/molmil-images/mine/3bmp) | |
3BK3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3bk3 by Molmil](/molmil-images/mine/3bk3) | |
2B0U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2b0u by Molmil](/molmil-images/mine/2b0u) | The Structure of the Follistatin:Activin Complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Follistatin, IRIDIUM (III) ION, ... | Authors: | Thompson, T.B, Lerch, T.F, Cook, R.W, Woodruff, T.K, Jardetzky, T.S. | Deposit date: | 2005-09-14 | Release date: | 2005-10-11 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Structure of the Follistatin:Activin Complex Reveals Antagonism of Both Type I and Type II Receptor Binding. Dev.Cell, 9, 2005
|
|
8E3G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8e3g by Molmil](/molmil-images/mine/8e3g) | BMP2/GDF5 heterodimer | Descriptor: | Bone morphogenetic protein 2, GLYCEROL, Growth/differentiation factor 5 | Authors: | Gipson, G.R, Nolan, K.T, Thompson, T.B. | Deposit date: | 2022-08-17 | Release date: | 2023-02-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers. Bmc Biol., 21, 2023
|
|
4UI0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ui0 by Molmil](/molmil-images/mine/4ui0) | Crystal structure of the human RGMB-BMP2 complex, crystal form 2 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, BONE MORPHOGENETIC PROTEIN 2, CHLORIDE ION, ... | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | Deposit date: | 2015-03-27 | Release date: | 2015-05-06 | Last modified: | 2015-06-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein. Nat.Struct.Mol.Biol., 22, 2015
|
|
4UHZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4uhz by Molmil](/molmil-images/mine/4uhz) | Crystal structure of the human RGMB-BMP2 complex, crystal form 1 | Descriptor: | BONE MORPHOGENETIC PROTEIN 2, RGM DOMAIN FAMILY MEMBER B, SULFATE ION | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | Deposit date: | 2015-03-27 | Release date: | 2015-05-06 | Last modified: | 2015-06-17 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein. Nat.Struct.Mol.Biol., 22, 2015
|
|