Crystal structure of the activin/actrIIb extracellular domain

Summary for 1S4Y

DescriptorActivin receptor type IIB precursor, Inhibin beta A chain (3 entities in total)
Functional Keywordsstructural genomics, jcsg, transferase, psi, protein structure initiative, joint center for structural genomics
Biological sourceMus musculus (house mouse)
Cellular locationMembrane; Single-pass type I membrane protein P27040
Secreted P08476
Total number of polymer chains4
Total molecular weight49131.08
Greenwald, J.,Vega, M.E.,Allendorph, G.P.,Fischer, W.H.,Vale, W.,Choe, S.,Joint Center for Structural Genomics (JCSG) (deposition date: 2004-01-19, release date: 2004-08-10, Last modification date: 2011-07-13)
Primary citation
Greenwald, J.,Vega, M.E.,Allendorph, G.P.,Fischer, W.H.,Vale, W.,Choe, S.
A Flexible Activin Explains the Membrane-Dependent Cooperative Assembly of TGF-beta Family Receptors.
Mol.Cell, 15:485-489, 2004
PubMed: 15304227 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2004.07.011
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.28911 2.1% 11.4% 5.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02