2ARP

Activin A in complex with Fs12 fragment of follistatin

Summary for 2ARP

Related2ARV
DescriptorInhibin beta A chain, Follistatin, NICKEL (II) ION, ... (6 entities in total)
Functional Keywordscystine knot, disulfide rich, egf domain, kazal domain, protein complex, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
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Cellular locationSecreted P08476 P21674
Total number of polymer chains2
Total molecular weight30381.82
Authors
Harrington, A.E.,Morris-Triggs, S.A.,Ruotolo, B.T.,Robinson, C.V.,Ohnuma, S.,Hyvonen, M. (deposition date: 2005-08-21, release date: 2006-03-07, Last modification date: 2011-07-13)
Primary citation
Harrington, A.E.,Morris-Triggs, S.A.,Ruotolo, B.T.,Robinson, C.V.,Ohnuma, S.,Hyvonen, M.
Structural basis for the inhibition of activin signalling by follistatin
Embo J., 25:1035-1045, 2006
PubMed: 16482217 (PDB entries with the same primary citation)
DOI: 10.1038/sj.emboj.7601000
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26820 0.4% 7.2% 14.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02