2B0U

The Structure of the Follistatin:Activin Complex

Summary for 2B0U

DescriptorInhibin beta A chain, Follistatin, IRIDIUM (III) ION, ... (6 entities in total)
Functional Keywordsactivin, follistatin, tgf-beta, morphogen, inhibin, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted P08476 P19883
Total number of polymer chains4
Total molecular weight90655.58
Authors
Thompson, T.B.,Lerch, T.F.,Cook, R.W.,Woodruff, T.K.,Jardetzky, T.S. (deposition date: 2005-09-14, release date: 2005-10-11, Last modification date: 2017-10-11)
Primary citation
Thompson, T.B.,Lerch, T.F.,Cook, R.W.,Woodruff, T.K.,Jardetzky, T.S.
The Structure of the Follistatin:Activin Complex Reveals Antagonism of Both Type I and Type II Receptor Binding.
Dev.Cell, 9:535-543, 2005
PubMed: 16198295 (PDB entries with the same primary citation)
DOI: 10.1016/j.devcel.2005.09.008
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22439 1.8% 5.0% 8.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02