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2B0U

The Structure of the Follistatin:Activin Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0008083molecular_functiongrowth factor activity
B0005576cellular_componentextracellular region
B0008083molecular_functiongrowth factor activity
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001501biological_processskeletal system development
C0002244biological_processhematopoietic progenitor cell differentiation
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0007276biological_processgamete generation
C0007389biological_processpattern specification process
C0008585biological_processfemale gonad development
C0014070biological_processresponse to organic cyclic compound
C0030154biological_processcell differentiation
C0030509biological_processBMP signaling pathway
C0030510biological_processregulation of BMP signaling pathway
C0030857biological_processnegative regulation of epithelial cell differentiation
C0031069biological_processhair follicle morphogenesis
C0032926biological_processnegative regulation of activin receptor signaling pathway
C0036305biological_processameloblast differentiation
C0038102molecular_functionactivin receptor antagonist activity
C0042475biological_processodontogenesis of dentin-containing tooth
C0043395molecular_functionheparan sulfate proteoglycan binding
C0043616biological_processkeratinocyte proliferation
C0048185molecular_functionactivin binding
C0051798biological_processpositive regulation of hair follicle development
C0071363biological_processcellular response to growth factor stimulus
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001501biological_processskeletal system development
D0002244biological_processhematopoietic progenitor cell differentiation
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0007276biological_processgamete generation
D0007389biological_processpattern specification process
D0008585biological_processfemale gonad development
D0014070biological_processresponse to organic cyclic compound
D0030154biological_processcell differentiation
D0030509biological_processBMP signaling pathway
D0030510biological_processregulation of BMP signaling pathway
D0030857biological_processnegative regulation of epithelial cell differentiation
D0031069biological_processhair follicle morphogenesis
D0032926biological_processnegative regulation of activin receptor signaling pathway
D0036305biological_processameloblast differentiation
D0038102molecular_functionactivin receptor antagonist activity
D0042475biological_processodontogenesis of dentin-containing tooth
D0043395molecular_functionheparan sulfate proteoglycan binding
D0043616biological_processkeratinocyte proliferation
D0048185molecular_functionactivin binding
D0051798biological_processpositive regulation of hair follicle development
D0071363biological_processcellular response to growth factor stimulus
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE IR3 B 502
ChainResidue
BGLN15
BHOH518

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE IR3 C 503
ChainResidue
CLYS282

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE IR3 C 505
ChainResidue
CLYS48
DHOH528

site_idAC4
Number of Residues1
DetailsBINDING SITE FOR RESIDUE MLI C 400
ChainResidue
CTHR261

site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE MLI A 401
ChainResidue
APHE17

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MLI A 402
ChainResidue
CCYS167
CHIS190
CLYS193
ALYS21
AASP22

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MLI A 403
ChainResidue
APRO32
ASER90
DLEU105
DASP106

site_idAC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MPD B 404
ChainResidue
BALA31
BPRO32
BSER90
BMET91
CLEU105
CASP106
CGLU126

Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IiaPsgYhanyCeGeC
ChainResidueDetails
AILE29-CYS44

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN95
CASN259
DASN95
DASN259

225158

PDB entries from 2024-09-18

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