X-Ray structure of Activin in complex with FSTL3

Summary for 3B4V

DescriptorInhibin beta A chain, follistatin-like 3, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywordsligand-inhibitor signalling complex, cleavage on pair of basic residues, glycoprotein, growth factor, hormone, secreted, nucleus, proto-oncogene, hormone regulator complex
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total molecular weight152645.57
Thompson, T.B. (deposition date: 2007-10-24, release date: 2008-09-02, Last modification date: 2020-07-29)
Primary citation
Stamler, R.,Keutmann, H.T.,Sidis, Y.,Kattamuri, C.,Schneyer, A.,Thompson, T.B.
The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity.
J.Biol.Chem., 283:32831-32838, 2008
PubMed: 18768470 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M801266200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2704 0.2% 2.6% 5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02