3B4V

X-Ray structure of Activin in complex with FSTL3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008083	molecular_function	growth factor activity
B	0005576	cellular_component	extracellular region
B	0008083	molecular_function	growth factor activity
C	0001503	biological_process	ossification
C	0001968	molecular_function	fibronectin binding
C	0002244	biological_process	hematopoietic progenitor cell differentiation
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0022409	biological_process	positive regulation of cell-cell adhesion
C	0030154	biological_process	cell differentiation
C	0030510	biological_process	regulation of BMP signaling pathway
C	0030514	biological_process	negative regulation of BMP signaling pathway
C	0032926	biological_process	negative regulation of activin receptor signaling pathway
C	0045671	biological_process	negative regulation of osteoclast differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0048185	molecular_function	activin binding
C	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
D	0001503	biological_process	ossification
D	0001968	molecular_function	fibronectin binding
D	0002244	biological_process	hematopoietic progenitor cell differentiation
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0022409	biological_process	positive regulation of cell-cell adhesion
D	0030154	biological_process	cell differentiation
D	0030510	biological_process	regulation of BMP signaling pathway
D	0030514	biological_process	negative regulation of BMP signaling pathway
D	0032926	biological_process	negative regulation of activin receptor signaling pathway
D	0045671	biological_process	negative regulation of osteoclast differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0048185	molecular_function	activin binding
D	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
E	0005576	cellular_component	extracellular region
E	0008083	molecular_function	growth factor activity
F	0005576	cellular_component	extracellular region
F	0008083	molecular_function	growth factor activity
G	0001503	biological_process	ossification
G	0001968	molecular_function	fibronectin binding
G	0002244	biological_process	hematopoietic progenitor cell differentiation
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0022409	biological_process	positive regulation of cell-cell adhesion
G	0030154	biological_process	cell differentiation
G	0030510	biological_process	regulation of BMP signaling pathway
G	0030514	biological_process	negative regulation of BMP signaling pathway
G	0032926	biological_process	negative regulation of activin receptor signaling pathway
G	0045671	biological_process	negative regulation of osteoclast differentiation
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0048185	molecular_function	activin binding
G	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
H	0001503	biological_process	ossification
H	0001968	molecular_function	fibronectin binding
H	0002244	biological_process	hematopoietic progenitor cell differentiation
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005788	cellular_component	endoplasmic reticulum lumen
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0022409	biological_process	positive regulation of cell-cell adhesion
H	0030154	biological_process	cell differentiation
H	0030510	biological_process	regulation of BMP signaling pathway
H	0030514	biological_process	negative regulation of BMP signaling pathway
H	0032926	biological_process	negative regulation of activin receptor signaling pathway
H	0045671	biological_process	negative regulation of osteoclast differentiation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0048185	molecular_function	activin binding
H	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00250
Number of Residues	16
Details	TGF_BETA_1 TGF-beta family signature. IiaPsgYhanyCeGeC

Chain	Residue	Details
A	ILE29-CYS44

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
C	SER229
D	SER229
G	SER229
H	SER229

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22052913

Chain	Residue	Details
C	ASN47
D	ASN47
G	ASN47
H	ASN47

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18768470

Chain	Residue	Details
C	ASN189
D	ASN189
G	ASN189
H	ASN189

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