Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3B4V

X-Ray structure of Activin in complex with FSTL3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008083	molecular_function	growth factor activity
B	0005576	cellular_component	extracellular region
B	0008083	molecular_function	growth factor activity
C	0001503	biological_process	ossification
C	0001968	molecular_function	fibronectin binding
C	0002244	biological_process	hematopoietic progenitor cell differentiation
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0006351	biological_process	DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0022409	biological_process	positive regulation of cell-cell adhesion
C	0030154	biological_process	cell differentiation
C	0030510	biological_process	regulation of BMP signaling pathway
C	0030514	biological_process	negative regulation of BMP signaling pathway
C	0032926	biological_process	negative regulation of activin receptor signaling pathway
C	0045671	biological_process	negative regulation of osteoclast differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0048185	molecular_function	activin binding
C	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
D	0001503	biological_process	ossification
D	0001968	molecular_function	fibronectin binding
D	0002244	biological_process	hematopoietic progenitor cell differentiation
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0006351	biological_process	DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0022409	biological_process	positive regulation of cell-cell adhesion
D	0030154	biological_process	cell differentiation
D	0030510	biological_process	regulation of BMP signaling pathway
D	0030514	biological_process	negative regulation of BMP signaling pathway
D	0032926	biological_process	negative regulation of activin receptor signaling pathway
D	0045671	biological_process	negative regulation of osteoclast differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0048185	molecular_function	activin binding
D	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
E	0005576	cellular_component	extracellular region
E	0008083	molecular_function	growth factor activity
F	0005576	cellular_component	extracellular region
F	0008083	molecular_function	growth factor activity
G	0001503	biological_process	ossification
G	0001968	molecular_function	fibronectin binding
G	0002244	biological_process	hematopoietic progenitor cell differentiation
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0006351	biological_process	DNA-templated transcription
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0022409	biological_process	positive regulation of cell-cell adhesion
G	0030154	biological_process	cell differentiation
G	0030510	biological_process	regulation of BMP signaling pathway
G	0030514	biological_process	negative regulation of BMP signaling pathway
G	0032926	biological_process	negative regulation of activin receptor signaling pathway
G	0045671	biological_process	negative regulation of osteoclast differentiation
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0048185	molecular_function	activin binding
G	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
H	0001503	biological_process	ossification
H	0001968	molecular_function	fibronectin binding
H	0002244	biological_process	hematopoietic progenitor cell differentiation
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005788	cellular_component	endoplasmic reticulum lumen
H	0006351	biological_process	DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0022409	biological_process	positive regulation of cell-cell adhesion
H	0030154	biological_process	cell differentiation
H	0030510	biological_process	regulation of BMP signaling pathway
H	0030514	biological_process	negative regulation of BMP signaling pathway
H	0032926	biological_process	negative regulation of activin receptor signaling pathway
H	0045671	biological_process	negative regulation of osteoclast differentiation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0048185	molecular_function	activin binding
H	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00250
Number of Residues	16
Details	TGF_BETA_1 TGF-beta family signature. IiaPsgYhanyCeGeC

Chain	Residue	Details
A	ILE29-CYS44

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	284
Details	Domain: {"description":"TB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00697","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	92
Details	Domain: {"description":"Follistatin-like 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22052913","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18768470","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Domain: {"description":"Follistatin-like 1"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	56
Details	Domain: {"description":"Kazal-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00798","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)